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首页> 外文期刊>Dementia and Geriatric Cognitive Disorders Extra >Changes of Myelin Organization in Patients with Alzheimer’s Disease Shown by q-Space Myelin Map Imaging
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Changes of Myelin Organization in Patients with Alzheimer’s Disease Shown by q-Space Myelin Map Imaging

机译：q-空间髓磷脂图成像显示阿尔茨海默氏病患者髓磷脂组织的变化

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Background: Recent studies detected the aberrant myelination of the central nervous system (CNS) in Alzheimer’s disease (AD). Here, we compared the change of myelination between patients with AD and controls by a novel magnetic resonance imaging modality, “q-space myelin map (MM) imaging.” Methods: Twenty patients with AD and 18 healthy subjects underwent MM imaging. We compared the MM metric between the 2 groups and examined the relationships between the metric and the clinical symptoms of AD. Results: AD patients showed a significant reduction of MM metric in the hippocampus, insula, precuneus, and anterior cingulate regions. There was also a significant negative correlation between the duration of illness and the MM metric in the temporoparietal region. Conclusion: Our findings suggest that MM imaging could be a clinically proper modality to estimate the myelination changes in AD patients.
机译：背景：最近的研究发现了阿尔茨海默氏病（AD）中枢神经系统（CNS）的异常髓鞘形成。在这里，我们通过一种新型的磁共振成像方式“ q空间髓磷脂图（MM）成像”比较了AD患者和对照组之间的髓鞘形成变化。方法：20例AD患者和18例健康受试者接受了MM成像。我们比较了两组之间的MM指标，并检查了该指标与AD临床症状之间的关系。结果：AD患者的海马区，岛状，前突和前扣带回区的MM度量显着降低。病程与颞顶区域的MM指标之间也存在显着的负相关。结论：我们的发现表明，MM成像可能是一种临床上合适的方式，可以估计AD患者的髓鞘改变。

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