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首页> 外文期刊>Dementia and Geriatric Cognitive Disorders Extra >Onset Patterns and Initial Symptoms of Dementia with Lewy Bodies: Possible Pathophysiological Diversities Deduced from a SPECT Study
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Onset Patterns and Initial Symptoms of Dementia with Lewy Bodies: Possible Pathophysiological Diversities Deduced from a SPECT Study

机译：路易体痴呆的发病模式和初始症状：从SPECT研究中推断出可能的病理生理差异

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Background/Aims: The aim of this study was to investigate onset patterns and initial symptoms in patients with dementia with Lewy bodies (DLB) and their association with SPECT findings. Methods: We studied 29 probable and 12 possible DLB patients. Onset was defined as ‘acute’ when symptoms (in various combinations) present within a few weeks or ‘chronic’ when a few symptoms present and progress during a longer period of time. Initial symptoms were dichotomized into ‘cognitive’ and ‘non-cognitive’. We conducted voxel-to-voxel statistical analyses of SPECT, and uptake deviations from age-matched controls were depicted with Z-scores. Results: In acute patients, decreases were more apparent in the bilateral frontal and temporal lobes, whereas chronic patients showed decreases in the bilateral occipital, posterior cingulate and precuneal regions. Differences in the left frontal and left posterior cingulate were significant and those in the left temporal region showed a tendency toward significance. Patients with cognitive symptoms demonstrated more marked decreases in the bilateral temporal, parietal, occipital, cingulate and precuneal regions. Differences in the left parietal area reached significance and the total decreases were larger in patients with cognitive than non-cognitive symptoms, with a trend toward significance. Conclusions: The multiplicity of onset patterns and initial symptoms may possibly be based on pathophysiological diversities in DLB.
机译：背景/目的：这项研究的目的是调查路易体（DLB）痴呆患者的发作方式和初始症状，以及它们与SPECT结果的关系。方法：我们研究了29位可能的DLB患者和12位可能的DLB患者。当症状（以各种组合形式）在几周内出现时，定义为“急性”，而当症状在较长时间内出现并发展时，则定义为“慢性”。最初的症状分为“认知”和“非认知”两类。我们对SPECT进行了逐像素统计分析，并使用Z评分描述了年龄匹配对照组的摄取偏差。结果：在急性患者中，双侧额叶和颞叶的下降更为明显，而慢性患者在双侧枕叶，扣带回和锥前区域均下降。左额叶和左后扣带有明显差异，而左颞区有显着性差异。有认知症状的患者表现出在双侧颞，顶叶，枕叶，扣带和c前区域的减少更为明显。有认知的患者左壁面积差异达到显着水平，总下降幅度大于非认知症状，并有显着趋势。结论：发病模式和初始症状的多样性可能是由于DLB的病理生理多样性所致。

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