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首页> 外文期刊>Dementia and Geriatric Cognitive Disorders Extra >Chronic Obstructive Pulmonary Disease Is Associated with Altered Neuropsychological Performance in Young Adults
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Chronic Obstructive Pulmonary Disease Is Associated with Altered Neuropsychological Performance in Young Adults

机译：慢性阻塞性肺疾病与年轻成人的神经心理功能改变有关

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Background: Subjects with ischemic lesions have an increased risk of dementia. In addition, Alzheimer’s disease (AD) and vascular cognitive impairment share many risk factors. These observations suggest that different diseases that cause altered blood perfusion of the brain or hypoxia promote AD neurodegeneration. In this case-control, cross-sectional study, we sought to test the hypothesis that hypoxia facilitates cognitive decline.Methods: We looked for altered neuropsychological performance in subjects with chronic obstructive pulmonary disease (COPD) without apparent cardio- or cerebrovascular diseases or risk factors for atherosclerosis. A selected, homogeneous group of workers from two ceramic factories in a small town of central Italy was enrolled in this study. Results: The COPD patients had a slightly, but significantly worse performance than controls in a number of neuropsychological tests. Conclusion: The findings are consistent with the working hypothesis that chronic hypoxia facilitates cognitive decline.
机译：背景：患有缺血性病变的受试者患痴呆症的风险增加。此外，阿尔茨海默氏病（AD）和血管性认知障碍也有许多危险因素。这些观察结果表明，引起大脑血液灌注改变或缺氧的不同疾病会促进AD神经变性。在这项病例对照的横断面研究中，我们试图检验缺氧促进认知功能下降的假设。方法：我们寻找患有慢性阻塞性肺疾病（COPD）且无明显心脑血管疾病或风险的受试者的神经心理学表现改变动脉粥样硬化的因素。来自意大利中部一个小镇的两家陶瓷工厂的一组特定的，均质的工人参加了这项研究。结果：在许多神经心理学测试中，COPD患者的表现比对照组稍差，但明显较对照组差。结论：这些发现与慢性缺氧促进认知能力下降的工作假设是一致的。

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