• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Dementia and Geriatric Cognitive Disorders Extra >Can the ‘Head-Turning Sign’ Be a Clinical Marker of Alzheimer’s Disease
【24h】

Can the ‘Head-Turning Sign’ Be a Clinical Marker of Alzheimer’s Disease

机译：“转头迹象”能否成为阿尔茨海默氏病的临床标志

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Aims: To investigate the incidence and severity of the ‘head-turning sign’ (HTS), i.e. turning the head back to the caregiver(s) for help, in patients with various dementias and discuss its clinical specificity in Alzheimer’s disease (AD). Methods: We investigated the incidence and severity of HTS while administering a short cognitive test (the revised Hasegawa Dementia Rating Scale: HDSR) in outpatients with AD [125 patients, including 4 with AD + vascular dementia (VaD)], 8 with amnestic mild cognitive impairment (aMCI), 34 with dementia with Lewy bodies (DLB), 8 with progressive supranuclear palsy (PSP) and 6 with VaD. Results: Significant differences were found among the 5 disease groups in the incidence and severity of HTS, and HDSR scores. Given the significant differences between AD and DLB in post hoc analyses, patients were dichotomized into AD-related (AD and aMCI) and AD-nonrelated (PSP, DLB and VaD) groups. Both incidence (41 vs. 17%, p = 0.002) and severity of HTS (0.80 ± 1.13 vs. 0.21 ± 0.60, p = 0.001) were significantly higher in the AD-related group, while average age and HDSR scores were comparable between both groups. AD-related disease, female gender and low HDSR score contributed significantly to the occurrence and severity of HTS. Conclusions: HTS can be a clinical marker of AD and aMCI, and may represent a type of excuse behavior as well as a sign of dependency on and trust in the caregivers.
机译：目的：研究患有各种痴呆症的患者的“头转弯征兆”（HTS）的发生率和严重性，即将头转回护理人员以寻求帮助，并讨论其在阿尔茨海默氏病（AD）中的临床特异性。方法：我们调查了门诊AD患者[125例，其中4例AD +血管性痴呆（VaD）]，8例轻度轻度遗忘症患者进行短期认知测验（修订后的长谷川痴呆评分量表：HDSR）时HTS的发生率和严重程度认知障碍（aMCI），路易体痴呆（DLB）34例，进行性核上性麻痹（PSP）8例，VaD 6例。结果：5个疾病组之间的HTS发生率和严重程度以及HDSR得分之间存在显着差异。考虑到事后分析中AD和DLB之间的显着差异，将患​​者分为AD相关组（AD和aMCI）和AD不相关组（PSP，DLB和VaD）。 AD相关组的发生率（41％vs. 17％，p = 0.002）和HTS严重程度（0.80±1.13 vs. 0.21±0.60，p = 0.001）均显着更高，而平均年龄和HDSR评分在两组。 AD相关疾病，女性性别和低HDSR得分显着影响HTS的发生和严重程度。结论：HTS可能是AD和aMCI的临床标志，可能代表一种借口行为以及对照顾者的依赖和信任。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号