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Neural Correlates of Stroop Performance in Alzheimer’s Disease: A FDG-PET Study

机译：FDG-PET研究表明，阿尔茨海默氏病与Stroop表现的神经相关

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Background/Aims: The Stroop test is commonly applied in elderly subjects for the evaluation of cognitive impairment related to Alzheimer’s disease (AD) and related disorders. This study aimed to investigate the functional neural correlates of the Stroop performance in AD. Methods: In 136 probable AD patients and 54 cognitively normal elderly, a [18F]-fluorodeoxyglucose positron emission tomography scan and Stroop Color Word Test (SCWT) were performed. The correlations between the Stroop effect, which was measured by 6 different scoring methods, and regional cerebral glucose metabolism (rCMglc) were explored using a region-of-interest (ROI) approach and voxel-based analysis. Results: Among 6 Stroop interference measures, only 2 scores, including the SCWT color-word (CW) score, were significantly correlated with rCMglc of the dorsolateral prefrontal and anterior cingulate ROIs. Voxel-based analysis revealed significant positive correlations between SCWT CW scores and rCMglc in the inferior parietal lobule, middle temporal gyrus and middle frontal gyrus. Such correlations remained significant only in the less severe AD group. Conclusion: In AD patients, the Stroop effect depends on the functional integrity of the prefrontal cortices. Some parietotemporal regions also appear to be responsible for the Stroop effect in AD individuals.
机译：背景/目的：Stroop测试通常用于老年受试者，以评估与阿尔茨海默氏病（AD）和相关疾病有关的认知障碍。这项研究旨在调查功能性神经相关的Stroop在AD中的表现。方法：在136名可能的AD患者和54名认知正常的老年人中，进行了[ 18 F]-氟脱氧葡萄糖正电子发射断层扫描和Stroop彩色文字测试（SCWT）。使用感兴趣区域（ROI）方法和基于体素的分析，探索了通过6种不同评分方法测得的Stroop效应与区域性脑葡萄糖代谢（rCMglc）之间的相关性。结果：在6种Stroop干扰措施中，只有2个得分（包括SCWT彩色单词（CW）得分）与背外侧前额叶和前扣带ROI的rCMglc显着相关。基于体素的分析显示，在顶下小叶，颞中回和额中回中，SCWT CW评分与rCMglc之间存在显着的正相关。仅在不太严重的AD组中这种相关性仍然显着。结论：在AD患者中，Stroop效应取决于前额叶皮质的功能完整性。在AD个体中，一些顶颞区也似乎对Stroop效应负责。

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