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首页> 外文期刊>Dementia and Geriatric Cognitive Disorders Extra >Amnestic Mild Cognitive Impairment and Early Alzheimer’s Disease in an Asian Memory Clinic – Evidence for a Clinical Spectrum
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Amnestic Mild Cognitive Impairment and Early Alzheimer’s Disease in an Asian Memory Clinic – Evidence for a Clinical Spectrum

机译：亚洲记忆诊所的轻度轻度认知障碍和早期阿尔茨海默氏病-临床范围的证据

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Objectives: To determine if mild cognitive impairment (MCI) represents a continuum of cognitive and functional deficits. Methods: Clinical data of 164 subjects with no dementia (ND, n = 52), uncertain dementia (n = 69), and mild probable Alzheimer’s disease (AD, n = 43) were reviewed. Uncertain dementia patients were classified as pre-MCI (n = 11), early amnestic MCI (e-aMCI, n = 15) and late amnestic MCI (l-aMCI, n = 15). Cognitive assessments [Chinese Mini-Mental State Examination (CMMSE) and a validated neuropsychological battery], functional assessments (Lawton’s scale for instrumental activities of daily living) and neuroimaging (ischemic lesions and medial temporal lobe atrophy) were reviewed. Results: ND, aMCI and mild AD subjects demonstrated a significant trend for worsening performance for all cognitive and functional measures (ANOVA, p < 0.05). Pre-MCI subjects performed significantly better than aMCI subjects in all verbal memory domains (p < 0.001), while l-aMCI had worse functional performance (p = 0.007), a trend towards greater depressive symptoms (p = 0.05) and higher medial temporal lobe atrophy scores (p = 0.06). l-aMCI subjects were more likely than either pre-MCI or e-aMCI to progress to dementia over a mean follow-up period of 2.5 years (46.7 vs. 9.1 and 20.0%, respectively). Conclusions: Clinical delineation of aMCI allows the differentiation of those likely to progress for better correlation to biomarker development.
机译：目的：确定轻度认知障碍（MCI）是否代表认知和功能缺陷的连续体。方法：回顾了164例无痴呆（ND，n = 52），不确定性痴呆（n = 69）和轻度可能的阿尔茨海默病（AD，n = 43）的受试者的临床资料。不确定的痴呆患者分为MCI前（n = 11），早期遗忘MCI（e-aMCI，n = 15）和晚期遗忘MCI（l-aMCI，n = 15）。回顾了认知评估（中国小精神状态检查（CMMSE）和经过验证的神经心理状态），功能评估（劳顿的日常生活工具活动量表）和神经影像（缺血性病变和颞叶内侧萎缩）。结果：ND，aMCI和轻度AD受试者在所有认知和功能指标上均表现出明显的病情恶化趋势（ANOVA，p <0.05）。在所有言语记忆域中，MCI之前的受试者的表现均显着优于aMCI受试者（p <0.001），而l-aMCI的功能表现较差（p = 0.007），抑郁症状的趋势（p = 0.05）和内侧颞部较高肺叶萎缩评分（p = 0.06）。 I-aMCI受试者比前MCI或e-aMCI在平均2.5年的随访期内发展为痴呆的可能性更高（分别为46.7和9.1和20.0％）。结论：aMCI的临床描述可以区分可能进展的患者，以更好地与生物标志物的发展相关。

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