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The First Report of a Patient with Probable Variant Creutzfeldt-Jakob Disease in Turkey

机译:土耳其一名可能患有Creutzfeldt-Jakob变异病的患者的首次报道

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Variant Creutzfeldt-Jakob disease (vCJD) was first reported in the UK in 1996. Here, we report the first Turkish case of vCJD. A 47-year-old man, who has never lived outside of Turkey and had had no transfusion, was admitted to the University Hospital with speech disorder, cognitive decline and ataxia following depression, irritability, and personality change. The immunoassay of the 14-3-3 protein in the cerebrospinal fluid was negative. Brain magnetic resonance imaging revealed high-signal lesions involving the bilateral caudate and lentiform nucleus on T2- and diffusion-weighted imaging. The patient developed akinetic mutism 10 months after disease onset. The clinical presentation and neuroimaging findings were compatible with the vCJD cases reported since 1996 and met the World Health Organization’s case definition for probable vCJD.
机译:变种克雅氏病(vCJD)最早于1996年在英国报道。在这里,我们报道了土耳其的第一例vCJD病例。一名47岁的男子从未住过土耳其,也没有输血,他因语言障碍,认知能力下降和抑郁,易怒和性格改变而共济失调入大学医院。脑脊液中14-3-3蛋白的免疫测定为阴性。脑磁共振成像在T 2 -和弥散加权成像中发现了高信号病变,累及双侧尾状和半形核。病人发病后10个月出现了运动性mut默症。临床表现和神经影像学发现与1996年以来报道的vCJD病例相符,符合世界卫生组织对可能的vCJD的病例定义。

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