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A Longitudinal Study of Physical Function in Patients with Early-Onset Dementia

机译：早发性痴呆患者身体机能的纵向研究

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Background: The aim of this study was to explore changes in mobility in terms of ambulation and transfer over 1 year in patients with early-onset Alzheimer’s disease (EOAD), and to compare mobility in EOAD with patients with other types of early-onset dementia (EOOD). Method: Forty-two patients with EOAD and 30 patients with EOOD were included. All patients were home-dwelling and had mild or moderate degree of dementia. Mobility was assessed using the Timed Up and Go Test (TUG), a modified version of the Clinical Outcome Variables Scale, timed stair walking, and timed rise from the floor. Results: The EOAD group performed significantly better than the EOOD group on all mobility tests. After 1 year, 25 persons with EOAD were tested again. The performance on TUG (p = 0.028) and stair walking (p = 0.02) had deteriorated at the 1-year follow-up in the EOAD group. Conclusion: Patients with EOAD performed better on mobility tasks than patients with EOOD, but their performance deteriorated at 1-year follow-up.
机译：背景：本研究的目的是探讨早发性阿尔茨海默氏病（EOAD）患者在1年多的移动和迁移方面的活动性变化，并比较EOAD与其他类型的早发性痴呆患者的活动性（EOOD）。方法：纳入42例EOAD患者和30例EOOD患者。所有患者均在家中，患有轻度或中度痴呆症。使用“定时出门测验”（TUG），临床结果变量量表的修订版，定时爬楼梯和定时从地板上抬起来评估活动能力。结果：在所有流动性测试中，EOAD组的表现均明显优于EOOD组。一年后，再次对25名EOAD患者进行了测试。在EOAD组的1年随访中，TUG（p = 0.028）和爬楼梯（p = 0.02）的表现有所下降。结论：EOAD患者在移动任务方面比EOOD患者表现更好，但是在1年的随访中他们的表现恶化。

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