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Serum Metabolomic Biomarkers of Dementia

机译：痴呆症的血清代谢组学生物标志物

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Aims: This study compared serum metabolites of demented patients (Alzheimer's disease and vascular dementia) and controls, and explored serum metabolite profiles of nondemented individuals 5 years preceding the diagnosis. Methods: Cognitively healthy participants were followed up for 5-20 years. Cognitive assessment, serum sampling, and diagnosis were completed every 5 years. Multivariate analyses were conducted on the metabolite profiles generated by gas chromatography/time-of-flight mass spectrometry. Results: A significant group separation was found between demented patients and controls, and between incident cases and controls. Metabolites that contributed in both analyses were 3,4-dihydroxybutanoic acid, docosapentaenoic acid, and uric acid. Conclusions: Serum metabolite profiles are altered in demented patients, and detectable up to 5 years preceding the diagnosis. Blood sampling can make an important contribution to the early prediction of conversion to dementia.
机译：目的：本研究比较了痴呆患者（阿尔茨海默氏病和血管性痴呆）和对照组的血清代谢产物，并探讨了诊断前5年非痴呆患者的血清代谢产物谱。方法：对认知健康的参与者进行了5-20年的随访。每5年完成一次认知评估，血清采样和诊断。对通过气相色谱/飞行时间质谱法生成的代谢物谱进行多变量分析。结果：痴呆患者和对照组之间以及事件病例和对照组之间存在显着的群体分离。在两个分析中都有贡献的代谢物是3,4-二羟基丁酸，十二碳五烯酸和尿酸。结论：痴呆患者的血清代谢产物发生改变，在诊断前长达5年可检测到。血液采样可以为早期预测转化为痴呆做出重要贡献。

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