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首页> 外文期刊>Dementia and Geriatric Cognitive Disorders Extra >The Extension of the German CERAD Neuropsychological Assessment Battery with Tests Assessing Subcortical, Executive and Frontal Functions Improves Accuracy in Dementia Diagnosis
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The Extension of the German CERAD Neuropsychological Assessment Battery with Tests Assessing Subcortical, Executive and Frontal Functions Improves Accuracy in Dementia Diagnosis

机译：通过评估皮层下，执行和额叶功能的测试来扩展德国CERAD神经心理学评估电池组，可提高痴呆症诊断的准确性

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Background/Aims: Alzheimer's disease (AD) is the most common form of dementia. Neuropsychological assessment of individuals with AD primarily focuses on tests of cortical functioning. However, in clinical practice, the underlying pathologies of dementia are unknown, and a focus on cortical functioning may neglect other domains of cognition, including subcortical and executive functioning. The current study aimed to improve the diagnostic discrimination ability of the Consortium to Establish a Registry for Alzheimer's Disease - Neuropsychological Assessment Battery (CERAD-NAB) by adding three tests of executive functioning and mental speed (Trail Making Tests A and B, S-Words). Methods: Logistic regression analyses of 594 normal controls (NC), 326 patients with mild AD and 224 patients with other types of dementia (OD) were carried out, and the area under the curve values were compared to those of CERAD-NAB alone. Results: All comparisons except AD-OD (65.5%) showed excellent classification rates (NC-AD: 92.7%; NC-OD: 89.0%; NC-all patients: 91.0%) and a superior diagnostic accuracy of the extended version. Conclusion: Our findings suggest that these three tests provide a sensible addition to the CERAD-NAB and can improve neuropsychological diagnosis of dementia.
机译：背景/目的：阿尔茨海默氏病（AD）是痴呆症的最常见形式。对患有AD的个体的神经心理学评估主要侧重于皮质功能的测试。然而，在临床实践中，痴呆症的潜在病理是未知的，对皮层功能的关注可能会忽略其他认知领域，包括皮层下和执行功能。当前的研究旨在通过增加执行功能和心理速度的三个测试（足迹制作测试A和B，S-Words）来提高财团建立阿尔茨海默氏病注册中心的诊断歧视能力-神经心理评估组（CERAD-NAB） ）。方法：对594名正常对照组（NC），326名轻度AD患者和224名其他类型的痴呆（OD）患者进行Logistic回归分析，并将曲线下面积与单独的CERAD-NAB进行比较。结果：除AD-OD（65.5％）以外的所有比较均显示出极好的分类率（NC-AD：92.7％; NC-OD：89.0％; NC-所有患者：91.0％），并且扩展版的诊断准确性更高。结论：我们的发现表明，这三种测试为CERAD-NAB提供了明智的补充，并可以改善痴呆症的神经心理学诊断。

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