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首页> 外文期刊>Dementia and Geriatric Cognitive Disorders Extra >Anxiety and Depression as Risk Factors in Frontotemporal Dementia and Alzheimer’s Disease: The HUNT Study
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Anxiety and Depression as Risk Factors in Frontotemporal Dementia and Alzheimer’s Disease: The HUNT Study

机译：焦虑和抑郁是额颞叶痴呆和阿尔茨海默氏病的危险因素：HUNT研究

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Background: The roles of both anxiety and depression as risk factors for frontotemporal dementia (FTD) and Alzheimer’s disease (AD) have not been previously investigated together. Objective: To study anxiety and depression as independent risk factors for FTD and AD. Methods: Eighty-four patients with FTD and 556 patients with AD were compared with 117 cognitively healthy (CH), elderly individuals. Both cases and controls were participants in the second Health Study of Nord-Tr?ndelag (HUNT2) from 1995 to 1997, in which depression and anxiety were assessed with the Hospital Anxiety and Depression Scale (HADS). Results: Significant associations were found between anxiety and FTD and between depression and AD. A significantly increased risk of developing FTD was observed in patients who had reported anxiety on the HADS (p = 0.017) (odds ratio [OR]: 2.947, 95% confidence interval [CI]: 1.209–7.158) and a significantly increased risk of developing AD was observed in patients who had reported depression on the HADS (p = 0.016) (OR: 4.389, 95% CI: 1.311–14.690). Conclusion: Our study findings suggest that anxiety and depression may play different roles as risk factors for FTD and AD.
机译：背景：焦虑和抑郁作为额颞叶痴呆（FTD）和阿尔茨海默氏病（AD）的危险因素的作用以前没有一起研究过。目的：研究焦虑和抑郁是FTD和AD的独立危险因素。方法：将84名FTD患者和556名AD患者与117名认知健康（CH）老年患者进行比较。病例和对照均参加了1995年至1997年第二次Nord-Tr？ndelag健康研究（HUNT2），其中抑郁症和焦虑症通过医院焦虑症和抑郁量表（HADS）进行评估。结果：焦虑与FTD之间，抑郁与AD之间存在显着相关性。报告患有HADS焦虑症的患者观察到发生FTD的风险显着增加（p = 0.017）（几率[OR]：2.947，95％置信区间[CI]：1.209-7.158），并且发生FTD的风险显着增加。在HADS发生抑郁的患者中观察到发展中的AD（p = 0.016）（OR：4.389，95％CI：1.311-14.690）。结论：我们的研究结果表明，焦虑和抑郁可能是FTD和AD的危险因素。

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