首页> 外文期刊>Journal of Epithelial Biology & Pharmacology >Electrolyte and Fluid Transport in Mesothelial Cells
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Electrolyte and Fluid Transport in Mesothelial Cells

机译:间皮细胞中的电解质和液体运输

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Mesothelial cells are specialized epithelial cells, which line the pleural, pericardial, and peritoneal cavities. Accumulatingevidence suggests that the monolayer of mesothelial cells is permeable to electrolyte and fluid, and therebygovern both fluid secretion and re-absorption in the serosal cavities. Disorders in these salt and fluid transport systemsmay be fundamental in the pathogenesis of pleural effusion, pericardial effusion, and ascites. In this review, we discussthe location, physiological function, and regulation of active transport (Na+-K+-ATPase) systems, cation and anion channels(Na+, K+, Cl-, and Ca2+ channels), antiport (exchangers) systems, and symport (co-transporters) systems, and waterchannels (aquaporins). These secretive and absorptive pathways across mesothelial monolayer cells for electrolytes andfluid may provide pivotal therapeutical targets for novel clinical intervention in edematous diseases of serous cavities.
机译:间皮细胞是专门的上皮细胞,排列在胸膜,心包膜和腹膜腔中。越来越多的证据表明,间皮细胞的单层可透过电解质和液体,从而控制浆腔内的液体分泌和再吸收。这些盐和液体输送系统的紊乱可能是胸腔积液,心包积液和腹水发病机理的基础。在这篇综述中,我们讨论了主动转运(Na + -K + -ATPase)系统,阳离子和阴离子通道(Na +,K +,Cl-和Ca2 +通道),反转运(交换子)系统和共转运的位置,生理功能和调控。 (共同运输)系统和水道(水通道蛋白)。这些跨间皮单层细胞的电解质和液体分泌和吸收途径可能为浆液性水肿疾病的新型临床干预提供关键的治疗靶点。

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