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首页> 外文期刊>Journal of Epithelial Biology & Pharmacology >Interactions between the Bronchial Epithelium and Fibrocytes in the Pathogenesis of Airway Remodeling in Asthma
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Interactions between the Bronchial Epithelium and Fibrocytes in the Pathogenesis of Airway Remodeling in Asthma

机译：哮喘气道重塑发病机制中支气管上皮细胞与纤维细胞之间的相互作用

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The histopathologic features of asthma include chronic airway inflammation, increased density of fibroblastsand myofibroblasts in the lamina propria and presence of structural abnormalities of the bronchial wall collectively referredto with the term “airway remodeling”. The newly emerged population of fibroblasts and myofibroblasts contributesto airway remodeling by producing excessive amounts of collagenous and non-collagenous extracellular matrix componentsin the subepithelial zone and by expanding the mass of contractile cells in the bronchial wall. A substantial proportionof these mesenchymal cells in asthma exhibit the phenotypic and functional characteristic of fibrocytes, which representa unique population of bone marrow-derived mesenchymal progenitors recruited to tissue sites from the circulation inresponse to injury or in chronic inflammatory conditions. Recent studies have demonstrated that the asthmatic bronchialepithelium is a major source of fibrocyte chemoattractants and growth factors. This review will focus on the novel observationssuggesting that asthmatic epithelial cells may play a key role in the development and progression of airway remodelingby promoting the recruitment and local differentiation of fibrocytes.
机译：哮喘的组织病理学特征包括慢性气道炎症，固有层中成纤维细胞和肌成纤维细胞密度增加以及支气管壁结构异常的存在，统称为“气道重塑”。新出现的成纤维细胞和成肌纤维细胞群体通过在上皮下区产生过量的胶原和非胶原细胞外基质成分，并扩大支气管壁中的收缩细胞质量，从而对气道重塑做出了贡献。在哮喘中，这些间充质细胞的很大一部分表现出纤维细胞的表型和功能特征，这代表了由骨髓循环产生的独特的骨髓间充质祖细胞群，这些细胞是从循环中招募到受伤或慢性炎症条件下的组织部位。最近的研究表明，哮喘支气管上皮细胞是纤维细胞趋化因子和生长因子的主要来源。这篇综述将集中在新发现上，即哮喘上皮细胞可能通过促进纤维细胞的募集和局部分化而在气道重塑的发展和进程中发挥关键作用。

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