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首页> 外文期刊>Journal of Feline Medicine and Surgery Open Reports >Successful treatment of feline leishmaniosis using a combination of allopurinol and N-methyl-glucamine antimoniate
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Successful treatment of feline leishmaniosis using a combination of allopurinol and N-methyl-glucamine antimoniate

机译：别嘌醇和N-甲基葡萄糖胺锑酸盐的组合成功治疗猫利什曼病

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This work describes the diagnosis and successful treatment of a 2-year-old domestic cat infected with Leishmania species and presenting fever, and ulcerative and nodular skin lesions after being treated for pyodermatitis for 1 year without clinical improvement. After anamnesis the cat was submitted to a complete clinical examination. Blood was collected for determination of haematological and biochemical parameters, detection of feline leukaemia virus (FeLV), feline immunodeficiency virus (FIV), feline coronavirus (FCoV) and Leishmania amastigotes. Fine-needle aspiration puncture from the skin nodules was also performed. After definitive diagnosis the animal was treated and followed up over a 2 year period. The animal tested negative for FIV-specific antibodies, FeLV antigen and feline coronavirus RNA. Leishmania amastigotes in the skin nodules were confirmed by cytology and molecular diagnosis. Treatment was initiated with allopurinol, resulting in a slight clinical improvement. Thus, N-methyl-glucamine antimoniate was added and administered for 30 days, with complete closure of the ulcerative lesions in the hindlimbs requiring a surgical approach. Close monitoring of the patient in the following 24 months indicated that combined therapy was safe and clinical cure was achieved without further relapses or side effects.
机译：这项工作描述了诊断为2岁的家猫，该猫感染了利什曼原虫种并在治疗脓皮炎1年后出现发烧，溃疡性和结节性皮肤病变，但无临床改善。记忆删除后，猫接受了完整的临床检查。收集血液以确定血液学和生化参数，检测猫白血病病毒（FeLV），猫免疫缺陷病毒（FIV），猫冠状病毒（FCoV）和利什曼原虫。还进行了从皮肤结节的细针穿刺穿刺。明确诊断后，对动物进行治疗，并在2年内进行随访。该动物测试的FIV特异性抗体，FeLV抗原和猫冠状病毒RNA阴性。通过细胞学和分子诊断证实了皮肤结节中的利什曼原虫amastigotes。用别嘌呤醇开始治疗，导致临床略有改善。因此，加入N-甲基-葡糖胺锑酸盐并施用30天，完全封闭后肢中的溃疡性病变，需要手术方法。在接下来的24个月中，对患者进行的密切监测表明，联合治疗是安全的，并且可以实现临床治愈，且无进一步复发或副作用。

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