• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Education and Health Promotion >The effect of melatonin on the lipid levels in menopausal women: A double-blind, controlled, clinical trial
【24h】

The effect of melatonin on the lipid levels in menopausal women: A double-blind, controlled, clinical trial

机译：褪黑激素对更年期妇女脂质水平的影响：一项双盲，对照，临床试验

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND: Cardiovascular diseases are the major public health problem in many countries and are responsible for more than half of the deaths in above 50-year-old women. The most common curable risk factor of these disorders is hypoestrogenemia resulting from menopause. The present study aimed to investigate the effect of melatonin on plasma lipid levels in menopausal women. MATERIALS AND METHODS: The present double-blind, placebo-controlled, clinical trial was conducted in 2013–2014 on 240 menopausal women between 40 and 60 years old referring to the Gynecology and obstetrics clinics of Shiraz University of Medical Sciences who were randomly divided into two groups. The intervention group received 3 mg melatonin tablets and the control group received the placebo for 3 months. The data were gathered using the demographic information questionnaire and lipid profile test before and 3 months after the intervention. Then, the data were analyzed through the SPSS statistical software (version 16). The repeated measures analysis of variance, the least significant difference, the independent-sample t , the Chi-square, and Fisher's exact tests were done for data analysis. RESULTS: The two study groups were similar regarding the demographic and clinical variables at the beginning of the study. In the melatonin group, the amount of triglyceride increased from 140.34 ± 48.29 before the study to 151.24 ± 54.60 3 months after the intervention and no significant difference was observed between the two groups in this regard (confidence interval [CI] = 95%, P 0.05). In addition, no significant difference was found between the two groups concerning low-density lipoprotein cholesterol level (CI = 95%, P = 0.125). CONCLUSION: Melatonin was not effective in reduction of lipid levels. However, further controlled studies are needed to be conducted on the issue.
机译：背景：心血管疾病是许多国家/地区的主要公共卫生问题，是50岁以上妇女半数以上死亡的原因。这些疾病最常见的可治愈风险因素是由更年期引起的低雌激素血症。本研究旨在探讨褪黑激素对更年期妇女血浆脂质水平的影响。材料与方法：本双盲，安慰剂对照的临床试验于2013年至2014年对240名40至60岁的绝经女性进行了研究，其中包括设拉子医科大学的妇产科门诊，她们被随机分为两部分。两组。干预组接受3 mg褪黑激素片剂，对照组接受安慰剂3个月。在干预前和干预后三个月，使用人口统计学信息问卷和脂质分布测试收集数据。然后，通过SPSS统计软件（版本16）分析数据。进行了方差，最小显着差异，独立样本t，卡方和Fisher精确检验的重复测量分析，以进行数据分析。结果：在研究开始时，两个研究组在人口统计学和临床​​变量方面相似。在褪黑激素组中，甘油三酯的含量从研究前的140.34±48.29增加到干预后3个月的151.24±54.60，在这方面两组之间没有观察到显着差异（置信区间[CI] = 95％，P > 0.05）。此外，两组在低密度脂蛋白胆固醇水平方面没有发现显着差异（CI = 95％，P = 0.125）。结论：褪黑激素不能有效降低血脂水平。但是，需要对此问题进行进一步的对照研究。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号