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首页> 外文期刊>Journal of genetics >F1 hybrids of BALB/c and C57BL/6 mouse strains respond differently to low-dose ionizing radiation exposure
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F1 hybrids of BALB/c and C57BL/6 mouse strains respond differently to low-dose ionizing radiation exposure

机译：BALB / c和C57BL / 6小鼠品系的F1杂种对低剂量电离辐射暴露的反应不同

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There are evidences to show that response to ionizing radiations have genetic influence. To investigate this further, reciprocal F1 hybrids were genereted by crossbreeding the radiation-susceptible BALB/c mouse strain with resistant C57BL/6 in a sex-specific manner (BALB/ca???—C57BL/6a?€ = B6BcF1; C57BL/6a???— BALB/ca?€ =BcB6F1). These hybrids were compared with each other and to the parental strains with respect to transcriptional responses to low-dose ionizing radiation exposure (LDIR). The two F1 hybrids showed drastic differences in their gene expression profiles to ionizing radiation exposure particularly in case of the genes involved in DNA damage response and repair process. Also, the inheritance pattern of the gene expression was found to be complex and could not be explained solely on the basis of parental expression pattern. It was concluded that there is a differential transmission of susceptible trait alleles from the parents to F1 progeny which is dependent on the sex of the parent mouse strain used to set up the crosses and other environmental factors.
机译：有证据表明，对电离辐射的反应具有遗传影响。为了进一步研究这一点，通过以性别特异性方式将抗辐射的BALB / c小鼠品系与抗性C57BL / 6进行杂交，从而繁殖出互惠的F1杂种（BALB / ca ^ -C57BL / 6a = B6BcF1; C57BL / 6a ???-BALB / ca？= BcB6F1）。将这些杂种彼此比较，并与亲本菌株进行比较，以了解对低剂量电离辐射暴露（LDIR）的转录反应。这两个F1杂种在电离辐射暴露中的基因表达谱上显示出巨大差异，特别是在涉及DNA损伤应答和修复过程的基因的情况下。另外，发现基因表达的遗传模式是复杂的，不能仅基于亲本表达模式来解释。得出的结论是，易感性状等位基因从亲本向F1后代的传递不同，这取决于用于设置杂交的亲本小鼠品系的性别和其他环境因素。

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