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首页> 外文期刊>Journal of genetics >Association of IL-6 and MMP-3 gene polymorphisms with susceptibility to adolescent idiopathic scoliosis: a meta-analysis
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Association of IL-6 and MMP-3 gene polymorphisms with susceptibility to adolescent idiopathic scoliosis: a meta-analysis

机译：IL-6和MMP-3基因多态性与青少年特发性脊柱侧凸易感性的关联：一项荟萃分析

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Recently, several institutions have investigated the associations of MMP-3-1171 5A/6A and IL-6-174-G/C gene polymorphisms with adolescent idiopathic scoliosis (AIS), while reports from different institutions are not consistent. Therefore, we,comprehensively and systematically performed this meta-analysis to detect whether the two gene polymorphisms are correlated with AIS. From January 1994 to October 2015, all casea€“control studies focussed on the relationship between the two a forementioned gene polymorphisms and the susceptibility to AIS were retrieved from bibliographic databases. A total of 16 articles were found, of which five consisted of 944 cases and 1177 controls, were finally included after being assessed by two reviewers. We calculated the pooled odds ratio (OR) with 95% confidence interval (95% CI) to assess the associations. The pooled data analyses were based on allele contrast, homozygote, heterozygote, dominant and recessive models. Overall, there was no significant association of IL-6-174-G/C gene polymorphism with AIS risk. Significant association was observedin homozygote model of MMP-3-1171-5A/6A gene polymorphism (5A5A versus 6A6A: OR= 1.69, 95% CI = 1.11a€“2.58,P =0.02). When stratified into Caucasian and Asian populations, positive association was found in Caucasian population(5A versus 6A: OR =1.43, 95% CI=1.11a€“1.84, P= 0.006; 5A5A versus 6A6A: OR = 1.90, 95% CI=1.13a€“3.19, P= 0.015); however, there was no significant association in Asian population. The present study concluded that 5A5A genotype of MMP-3-1171 5A/6A gene polymorphism was associated with AIS, especially in Caucasian population. However, no significant association was detected between IL-6-174-G/C gene polymorphism and AIS.
机译：最近，一些机构研究了MMP-3-1171 5A / 6A和IL-6-174-G / C基因多态性与青少年特发性脊柱侧凸（AIS）的关联，但来自不同机构的报道并不一致。因此，我们全面系统地进行了这项荟萃分析，以检测这两个基因多态性是否与AIS相关。从1994年1月至2015年10月，所有案例研究均集中于上述两个基因多态性之间的关系，并从书目数据库中检索了对AIS的易感性。总共找到16篇文章，其中5篇由944例病例和1177例对照组成，经两名审稿人评估后最终被纳入。我们计算了95％置信区间（95％CI）的合并比值比（OR），以评估相关性。汇总数据分析基于等位基因对比，纯合，杂合，显性和隐性模型。总体而言，IL-6-174-G / C基因多态性与AIS风险没有显着相关性。在MMP-3-1171-5A / 6A基因纯合子模型中观察到显着关联（5A5A对6A6A：OR = 1.69，95％CI = 1.11a-2.58，P = 0.02）。当按白种人和亚洲人群分层时，在白种人人群中发现正相关（5A对6A：OR = 1.43，95％CI = 1.11a-1.84a，P = 0.006; 5A5A对6A6A：OR = 1.90，95％CI = 1.13a-3.19，P ＝ 0.015）;但是，亚洲人口之间没有显着的联系。本研究得出的结论是，MMP-3-1171 5A / 6A基因多态性的5A5A基因型与AIS相关，特别是在白种人中。但是，IL-6-174-G / C基因多态性与AIS之间未发现明显关联。

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