...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of genetics >Genetic basis of interindividual susceptibility to cancer cachexia: selection of potential candidate gene polymorphisms for association studies
【24h】

Genetic basis of interindividual susceptibility to cancer cachexia: selection of potential candidate gene polymorphisms for association studies

机译：个体间癌症恶病质易感性的遗传基础：关联研究潜在候选基因多态性的选择

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Cancer cachexia is a complex and multifactorial disease. Evolving definitions highlight the fact that a diverse range of biological processes contribute to cancer cachexia. Part of the variation in who will and who will not develop cancer cachexia may be genetically determined. As new definitions, classifications and biological targets continue to evolve, there is a need for reappraisal of the literature for future candidate association studies. This review summarizes genes identified or implicated as well as putative candidate genes contributing to cachexia, identified through diverse technology platforms and model systems to further guide association studies. A systematic search covering 1986a€“2012 was performed for potential candidate genes / genetic polymorphisms relating to cancer cachexia. All candidate genes were reviewed for functional polymorphisms or clinically significant polymorphisms associated with cachexia using the OMIM and GeneRIF databases. Pathway analysis software was used to reveal possible network associations between genes. Functionality of SNPs/genes was explored based on published literature, algorithms for detecting putative deleterious SNPs and interrogating the database for expression of quantitative trait loci (eQTLs). A total of 154 genes associated with cancer cachexia were identified and explored for functional polymorphisms. Of these 154 genes, 119 had a combined total of 281 polymorphisms with functional and/or clinical significance in terms of cachexia associated with them. Of these, 80 polymorphisms (in 51 genes) were replicated in more than one study with 24 polymorphisms found to influence two or more hallmarks of cachexia (i.e., inflammation, loss of fat mass and/or lean mass and reduced survival). Selection of candidate genes and polymorphisms is a key element of multigene study design. The present study provides a contemporary basis to select genes and/or polymorphisms for further association studies in cancer cachexia, and to develop their potential as susceptibility biomarkers of cachexia.
机译：癌症恶病质是一种复杂的多因素疾病。不断发展的定义突出了以下事实：多种生物过程均导致癌症恶病质。谁会和谁不会发展癌症恶病质的部分变异可能是由基因决定的。随着新的定义，分类和生物学目标的不断发展，有必要对文献进行重新评估以用于未来的候选者关联研究。这篇综述总结了通过多种技术平台和模型系统鉴定出的与恶病质有关的已鉴定或涉及的基因以及可能的候选基因，以进一步指导关联研究。对1986年至2012年进行了系统检索，以寻找与癌症恶病质有关的潜在候选基因/遗传多态性。使用OMIM和GeneRIF数据库，对所有候选基因的功能多态性或与恶病质相关的临床上显着的多态性进行了审查。使用路径分析软件来揭示基因之间可能的网络关联。基于已发表的文献，用于检测假定的有害SNP并询问数据库以表达数量性状基因座（eQTL）的算法，探索了SNP /基因的功能。总共鉴定了154个与癌症恶病质相关的基因，并探讨了其功能多态性。在这154个基因中，有119个具有总共281个多态性，在与恶病质相关的功能和/或临床意义上。其中，在一项以上的研究中复制了80种多态性（共51个基因），发现24种多态性会影响恶病质的两个或多个特征（即炎症，脂肪和/或瘦肉减少和存活率降低）。候选基因和多态性的选择是多基因研究设计的关键要素。本研究提供了当代的基础，以选择基因和/或多态性用于癌症恶病质的进一步关联研究，并开发它们作为恶病质易感性生物标志物的潜力。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号