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首页> 外文期刊>Journal of Eating Disorders >A retrospective analysis of biochemical and haematological parameters in patients with eating disorders
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A retrospective analysis of biochemical and haematological parameters in patients with eating disorders

机译：进食障碍患者生化和血液学参数的回顾性分析

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Background The objective of the study was to determine whether levels of biochemical and haematological parameters in patients with eating disorders (EDs) varied from the general population. Whilst dietary restrictions can lead to nutritional deficiencies, specific abnormalities may be relevant to the diagnosis, pathogenesis and treatment of EDs. Methods With ethics approval and informed consent, a retrospective chart audit was conducted of 113 patients with EDs at a general practice in Brisbane, Australia. This was analysed first as a total group (TG) and then in 4 ED subgroups: Anorexia nervosa (AN), Bulimia nervosa (BN), ED Not Otherwise Specified (EDNOS), and AN/BN. Eighteen parameters were assessed at or near first presentation: cholesterol, folate, vitamin B12, magnesium, manganese, zinc, calcium, potassium, urate, sodium, albumin, phosphate, ferritin, vitamin D, white cell count, neutrophils, red cell count and platelets. Results were analysed using IBM SPSS 21 and Microsoft Excel 2013 by two-tailed, one-sample t-tests (TG and 4 subgroups) and chi-square tests (TG only) and compared to the population mean standards. Results for the TG and each subgroup individually were then compared with the known reference interval (RI). Results For the total sample, t-tests showed significant differences for all parameters ( p C onclusions At diagnosis, in patients with EDs, there are often significant differences in multiple haematological and biochemical parameters. Early identification of these abnormalities may provide additional avenues of ED treatment through supplementation and dietary guidance, and may be used to reinforce negative impacts on health caused by the ED to the patient, their family and their treatment team (general practitioner, dietitian and mental health professionals). Study data would support routine measurement of a full blood count and electrolytes, phosphate, magnesium, liver function tests, ferritin, vitamin B12, red cell folate, vitamin D, manganese and zinc for all patients at first presentation with an ED.
机译：背景研究的目的是确定进食障碍（ED）患者的生化和血液学参数水平是否与一般人群不同。尽管饮食限制会导致营养不足，但特定的异常可能与ED的诊断，发病机理和治疗有关。方法在伦理学批准和知情同意的情况下，对澳大利亚布里斯班的113名ED患者进行回顾性图表审核。首先将其作为总组（TG）进行分析，然后在4个ED子组中进行分析：神经性厌食症（AN），神经性贪食症（BN），未另外指定的ED（EDNOS）和AN / BN。在首次出现时或接近出现时评估了18个参数：胆固醇，叶酸，维生素B12，镁，锰，锌，钙，钾，尿酸盐，钠，白蛋白，磷酸盐，铁蛋白，维生素D，白细胞计数，中性粒细胞，红细胞计数和血小板。使用IBM SPSS 21和Microsoft Excel 2013通过两尾一样本t检验（TG和4个子组）和卡方检验（仅TG）分析结果，并与总体平均标准进行比较。然后将TG和每个亚组的结果分别与已知参考区间（RI）进行比较。结果对于总样本，t检验显示所有参数均存在显着差异（p C包含）在诊断时，EDs患者的多个血液学和生化指标通常存在显着差异，及早发现这些异常可能为ED提供了其他途径通过补充和饮食指导进行治疗，可用于加强ED对患者，其家人及其治疗团队（全科医生，营养师和精神卫生专业人员）对健康的负面影响，研究数据将支持常规测量首次接受ED检查的所有患者的全血细胞计数和电解质，磷酸盐，镁，肝功能测试，铁蛋白，维生素B12，红细胞叶酸，维生素D，锰和锌。

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