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首页> 外文期刊>Journal of Food Technology >Optimal Extraction of Glycyrrhetinic Acid Froml icorice Root
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Optimal Extraction of Glycyrrhetinic Acid Froml icorice Root

机译：甘草次黄甘草根的最佳提取工艺

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摘要

Licorice is a self-propelling plant that has many applications in pharmaceutical and food industries. Glycyrrhiza glabra is a kind of licorice whose main active constituentis a triterpenoid saponin called glycyrrhizin. If ether bound of glycyrrhizin is broken,it would loss its sweet taste and converts to glycyrrhetinic acid which is used as ananti-inflammatory agent. In order to produce glycyrrhetinic acid, glycyrrhizin without isolation is hydrolyzed in an acidic medium to release glycyrrhetinic acid. After filtration, glycyrrhetinic acid is extracted from resulting cake by ethyl acetate. The extract is then evaporated and the resulting solution is acetylated to produce glycyrrhetinic acid acetate. The ester is then purified by hexane and hydrolyzed with sodium hydroxide to produce glycyrrhetinic acid. The glycyrrhetinic acid produced in this way is dissolved in methanol and decolorized by activated carbon. Finally, water is added to solution to precipitate white glycyrrhetinic acid, which is purified by crystallization in aqueous ethanol to yield the final purified product.
机译：甘草是一种自走式植物，在制药和食品工业中有许多应用。甘草是一种甘草，其主要活性成分是三萜皂苷，称为甘草甜素。如果与甘草甜素结合的醚被破坏，它将失去其甜味并转化为用作抗炎药的甘草次酸。为了产生甘草次酸，将未经分离的甘草甜素在酸性介质中水解以释放甘草次酸。过滤后，用乙酸乙酯从所得饼中提取甘草次酸。然后将萃取液蒸发并将所得溶液乙酰化以产生甘草次酸乙酸酯。然后将该酯用己烷纯化并用氢氧化钠水解以产生甘草次酸。以这种方式产生的甘草次酸被溶解在甲醇中并被活性炭脱色。最后，将水加到溶液中以沉淀出白色的甘草次酸，将其通过在乙醇水溶液中结晶而纯化，得到最终的纯化产物。

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