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首页> 外文期刊>Journal of Extracellular Vesicles >Plasmalogen enrichment in exosomes secreted by a nematode parasite versus those derived from its mouse host: implications for exosome stability and biology
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Plasmalogen enrichment in exosomes secreted by a nematode parasite versus those derived from its mouse host: implications for exosome stability and biology

机译：线虫寄生虫分泌的外泌体与其小鼠宿主衍生的外泌体中的血浆致富素富集：对外泌体稳定性和生物学的影响

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Extracellular vesicles (EVs) mediate communication between cells and organisms across all 3 kingdoms of life. Several reports have demonstrated that EVs can transfer molecules between phylogenetically diverse species and can be used by parasites to alter the properties of the host environment. Whilst the concept of vesicle secretion and uptake is broad reaching, the molecular composition of these complexes is expected to be diverse based on the physiology and environmental niche of different organisms. Exosomes are one class of EVs originally defined based on their endocytic origin, as these derive from multivesicular bodies that then fuse with the plasma membrane releasing them into the extracellular environment. The term exosome has also been used to describe any small EVs recovered by high-speed ultracentrifugation, irrespective of origin since this is not always well characterized. Here, we use comparative global lipidomic analysis to examine the composition of EVs, which we term exosomes, that are se...
机译：细胞外囊泡（EVs）介导了生命的所有3个王国中细胞与生物之间的通信。几份报告表明，电动汽车可以在系统发生变化的物种之间转移分子，并且可以被寄生虫用来改变宿主环境的特性。尽管囊泡分泌和摄取的概念是广泛的，但是根据不同生物的生理学和环境生态位，预期这些复合物的分子组成是多样的。外来体是一类根据其内吞起源最初定义的EV，因为它们来自多囊泡体，然后与质膜融合，将其释放到细胞外环境中。外来体一词也已用于描述通过高速超速离心回收的任何小型电动汽车，而与来源无关，因为这种电动汽车并不总是很好地表征。在这里，我们使用比较全局脂质组学分析来检查电动汽车的组成，我们称其为外来体，它们是安全的。

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