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首页> 外文期刊>Journal of genetics >Genome-based exome sequencing analysis identifies GYG1, DIS3L and DDRGK1 are associated with myocardial infarction in Koreans
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Genome-based exome sequencing analysis identifies GYG1, DIS3L and DDRGK1 are associated with myocardial infarction in Koreans

机译：基于基因组的外显子组测序分析确定了GYG1，DIS3L和DDRGK1与韩国人的心肌梗死有关

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Myocardial infarction (MI) is a complex disease caused by combination of genetic and environmental factors. Although genome-wide association studies (GWAS) identified more than 46 risk loci which are associated with coronary artery disease and MI, most of the genetic variability inMI still remains undefined. Here, we screened the susceptibility loci for MI using exome sequencing and validated candidate variants in replication sets. We identified that three genes (GYG1, DIS3L and DDRGK1) were associated with MI at the discovery and replication stages. Further research will be required to determine the functional association of thesegenes with MI risk, and these associations have to be confirmed in other ethnic populations
机译：心肌梗塞（MI）是由遗传和环境因素共同导致的复杂疾病。尽管全基因组关联研究（GWAS）确定了46个以上与冠心病和MI相关的风险基因座，但MI的大多数遗传变异仍然不确定。在这里，我们使用外显子组测序筛选了MI的易感基因座，并验证了复制集中的候选变体。我们发现在发现和复制阶段，三个基因（GYG1，DIS3L和DDRGK1）与MI相关。需要进一步的研究来确定这些基因与MI风险的功能关联，并且这些关联必须在其他种族人群中得到证实

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