...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of genetics >Association of IL-10 gene (a?’1082AG, a?’819CT and a?’592CA) polymorphism and its serum level with metabolic syndrome of north Indian subjects
【24h】

Association of IL-10 gene (a?’1082AG, a?’819CT and a?’592CA) polymorphism and its serum level with metabolic syndrome of north Indian subjects

机译：IL-10基因（a？1082A> G，a？'819C> T和a？'592C> A）多态性及其血清水平与北印度受试者代谢综合征的相关性

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Metabolic syndrome (MetS) is an inflammatory disorder, in which various cytokines play important role in tilting balance towards disease state. Interleukin-10 (IL-10) is an important antiinflammatory cytokine, but its genetic polymorphisms and serum levels in Indian MetS subjects are unknown. Three IL-10 gene polymorphisms (a?’1082AG (rs1800896), a?’819CT (rs1800872) and a?’592CA (rs1800871)) were genotyped with PCR-RFLP in MetS subjects (n = 384) and age/sex matched control subjects (n = 386). Serum IL-10 was measured using enzyme-linked immunosorbent assay. Serum IL-10 level was significantly low in MetS subject and significantly correlated with clinicobiochemical parameters of MetS. Of three investigated promoter polymorphisms, IL-10 a€“819C T and a€“592CA were significantly associated with risk of MetS. The mutant alleles a?’819T and a?’592A of IL-10 gene polymorphism were significantly higher in MetS subjects compared to controls. Of the four different haplotypes obtained, common ACC haplotype and rare GTA haplotype of IL-10 polymorphisms were associated with MetS. The mean of fasting insulin and HOMA-IR were significantly different between the genotypes of both a?’819CT and a?’592CA polymorphisms of IL-10 in MetS subjects. These results suggested that polymorphisms in IL-10 gene (a?’819CT and a?’592CA), haplotypes (ACC and GTA) and serum level are significantly associated with risk of MetS. IL- 10 a?’819CT and a?’592CA polymorphic variants are also significantly associated with insulin level and homeostasis model assessment-insulin resistance in north Indian MetS subjects.
机译：代谢综合症（MetS）是一种炎症性疾病，其中各种细胞因子在向疾​​病状态倾斜的平衡中起重要作用。白细胞介素10（IL-10）是重要的抗炎细胞因子，但印度MetS受试者的基因多态性和血清水平尚不清楚。在MetS受试者中使用PCR-RFLP对三个IL-10基因多态性（a？1082A> G（rs1800896），a？'819C> T（rs1800872）和a？'592C> A（rs1800871））进行基因分型（n = 384） ）和年龄/性别匹配的对照组（n = 386）。使用酶联免疫吸附测定法测量血清IL-10。 MetS受试者的血清IL-10水平显着较低，并且与MetS的临床生化指标显着相关。在三个研究的启动子多态性中，IL-10 a“ 819C> T和a” 592C> A与MetS风险显着相关。与对照组相比，MetS受试者的IL-10基因多态性突变等位基因a？'819T和a？'592A显着更高。在获得的四种不同的单倍型中，IL-10多态性的常见ACC单倍型和罕见的GTA单倍型与MetS相关。在MetS受试者中，IL-10的α？819C> T和α？592C> A多态性的基因型之间，空腹胰岛素和HOMA-IR的平均值存在显着差异。这些结果表明，IL-10基因的多态性（a？819C> T和a？592C> A），单倍型（ACC和GTA）和血清水平与MetS风险显着相关。 IL-10 a？'819C> T和a？'592C> A多态性变异也与印度北部MetS受试者的胰岛素水平和稳态模型评估-胰岛素抵抗显着相关。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号