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首页> 外文期刊>Journal of genetics >Association of lactase 13910 C/T polymorphism with bone mineral density and fracture risk: a meta-analysis
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Association of lactase 13910 C/T polymorphism with bone mineral density and fracture risk: a meta-analysis

机译：乳糖酶13910 C / T基因多态性与骨矿物质密度和骨折风险的关联：一项荟萃分析

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Anumber of studies have investigated the association of lactase (LCT,C/T-13910) gene polymorphismwith bonemineral density (BMD) and fracture risk, but previous results were inconclusive. In this study, a meta-analysis was performed to quantifythe association of LCT (C/T-13910) polymorphism with BMD and fracture risk. Eligible publications were searched in the PubMed, Web of Science, Embase databases, Google Scholar, Yahoo and Baidu. Pooled weighed mean difference (WMD) or odds ratio (OR) with their 95% confidence interval (CI) were calculated using a fixed-effects or random-effects model. A total of nine articles with8871 subjects were investigated in the presentmeta-analysis. Overall, the TT/TC genotypes of LCT 13910 C/T polymorphism showed significantly higher BMD than those with the CC genotype at femur neck (FN) (WMD = 0.011 g/cm2, 95% CI = 0.004–0.018, P = 0.003). Besides, LCT 13910 C/T polymorphism may decrease the risk of any site fractures (for TT versus TC+CC, OR = 0.813, 95% CI = 0.704–0.938, P = 0.005; for T allele versus C allele, OR = 0.885, 95% CI = 0.792–0.989, P = 0.032). However, there was no significant association of LCT 13910 C/T polymorphism with BMD at lumbar spine and risk of vertebral fractures under all genetic contrast models (all P values were 0.05). The meta-analysis suggests that there are significant effects of LCT 13910 C/T polymorphism on BMD and fracture risk. Large-scale studies with different ethnic populations will be needed to further investigate the possible race-specific effect of LCT 13910 C/T polymorphism on BMD and fracture risk
机译：大量研究调查了乳糖酶（LCT，C / T-13910）基因多态性与骨矿物质密度（BMD）和骨折风险的关系，但先前的结果尚无定论。在这项研究中，进行了荟萃分析，以量化LCT（C / T-13910）多态性与骨密度和骨折风险的关系。在PubMed，Web of Science，Embase数据库，Google Scholar，Yahoo和Baidu中搜索了符合条件的出版物。使用固定效应或随机效应模型计算合并的加权平均差（WMD）或比值比（OR）及其95％置信区间（CI）。在本次元分析中，共调查了9篇文章与8871名受试者。总体而言，LCT 13910 C / T多态性的TT / TC基因型显示出的BMD明显高于股骨颈（FN）CC基因型的BMD（WMD = 0.011 g / cm2，95％CI = 0.004-0.018，P = 0.003） 。此外，LCT 13910 C / T多态性可降低任何部位骨折的风险（TT与TC + CC，OR = 0.813，95％CI = 0.704-0.938，P = 0.005; T等位基因与C等位基因，OR = 0.885 ，95％CI = 0.792–0.989，P = 0.032）。然而，在所有遗传对比模型下，腰椎的LCT 13910 C / T多态性与BMD和椎骨骨折风险均无显着相关性（所有P值均> 0.05）。荟萃分析表明，LCT 13910 C / T多态性对骨密度和骨折风险有显着影响。需要进一步研究不同种族的人群，以进一步研究LCT 13910 C / T多态性对BMD和骨折风险的种族特异性影响

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