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Mouse models of cataract

机译：白内障的小鼠模型

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Much of our knowledge about the function of genes in cataracts has been derived from the molecular analysis of spontaneous or induced mutations in the mouse. Mutations affecting the mouse lens can be identified easily by visual inspection, and a remarkable number of mutant lines have been characterized. In contrast to humans, most of the genetic mouse cataract models suffer from congenital cataracts, and only a few develop cataracts in old age. Therefore, the mouse cataract models contributed rather to the understanding of lens development than to the ageing process taking place in the lens. A prerequisite formolecular analysis is the chromosomal localization of the gene. In this review, several mouse models will be discussed with emphasis on the underlying genetic basis rather than the morphological features as exemplified by the following:the most frequent mutations in congenital cataracts affect genes coding for e???-crystallins (gene symbol: Cryg);
机译：我们对白内障基因功能的很多了解都来自对小鼠自发或诱发突变的分子分析。可以通过视觉检查很容易地识别出影响小鼠晶状体的突变，并且已经鉴定出数量众多的突变株。与人类相反，大多数遗传性小鼠白内障模型患有先天性白内障，只有少数在老年时会发展成白内障。因此，小鼠白内障模型更有助于理解晶状体发育，而不是有助于晶状体中发生的衰老过程。先决的大分子分析是该基因的染色体定位。在这篇综述中，将讨论几种小鼠模型，重点放在潜在的遗传基础上，而不是以下形式所表现出的形态特征：先天性白内障中最常见的突变会影响编码e ???-crystallins的基因（基因符号：Cryg ）;

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