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首页> 外文期刊>Journal of food and drug analysis >The detoxifying effects of structural elements of?persimmon tannin on Chinese cobra phospholipase Asub2/sub correlated with their structural disturbing effects well
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The detoxifying effects of structural elements of?persimmon tannin on Chinese cobra phospholipase Asub2/sub correlated with their structural disturbing effects well

机译：柿单宁结构元素对中华眼镜蛇磷脂酶A 2 的解毒作用与其结构扰动作用相关

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Abstract The effects of persimmon tannin (PT) characteristic structural elements on Naja atra phospholipase {A2} (PLA2)-induced lethality, myotoxicity, and hemolysis in mice models were determined. In addition, methods including surface plasmon resonance, dynamic light scattering, and Fourier transform infrared spectroscopy were explored to uncover the possible detoxifying mechanisms of {PT} on snake venom PLA2. Our results revealed that {PT} characteristic elements (EGCG, ECG, A-type {EGCG} dimer, and A-type {ECG} dimer) could neutralize the lethality, myotoxicity, and hemolysis of PLA2. Moreover, the detoxifying effects of the four structural elements correlated with their structural disturbing effects well. Our results proved that A-type {EGCG} dimer and A-type {ECG} dimer may be structural requirements for the detoxifying effects of PT. We propose that the high affinity of A-type {EGCG} dimer and A-type {ECG} dimer for {PLA2} and the considerable spatial structural disturbance of {PLA2} induced by the dimers may be responsible for their antilethality, antimyotoxicity, and antihemolysis on Chinese cobra {PLA2} in?vivo.
机译：摘要确定了柿子鞣质（PT）的特征性结构元素对Naja Atra磷脂酶{A2}（PLA2）致小鼠致死性，肌毒性和溶血的影响。此外，探索了包括表面等离振子共振，动态光散射和傅立叶变换红外光谱的方法，以揭示{PT}对蛇毒PLA2可能的解毒机理。我们的结果表明，{PT}特征元素（EGCG，ECG，A型{EGCG}二聚体和A型{ECG}二聚体）可以中和PLA2的致死性，肌毒性和溶血作用。而且，四种结构元素的解毒作用与其结构干扰作用良好相关。我们的结果证明，A型{EGCG}二聚体和A型{ECG}二聚体可能是PT解毒作用的结构要求。我们认为，A型{EGCG}二聚体和A型{ECG}二聚体对{PLA2}的高亲和力和由二聚体引起的{PLA2}的相当大的空间结构紊乱可能是它们的无亲和性，抗肌毒性和对中国眼镜蛇{PLA2}体内的抗溶血作用。

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