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首页> 外文期刊>Journal of Experimental Neuroscience >Slick (Kcnt2) Sodium-Activated Potassium Channels Limit Peptidergic Nociceptor Excitability and Hyperalgesia:
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Slick (Kcnt2) Sodium-Activated Potassium Channels Limit Peptidergic Nociceptor Excitability and Hyperalgesia:

机译：光滑的（Kcnt2）钠激活钾通道限制了肽能伤害感受器的兴奋性和痛觉过敏：

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The Slick (Kcnt2) sodium-activated potassium (KNa) channel is a rapidly gating and weakly voltage-dependent and sodium-dependent potassium channel with no clearly defined physiological function. Within the dorsal root ganglia (DRGs), we show Slick channels are exclusively expressed in small-sized and medium-sized calcitonin gene–related peptide (CGRP)-containing DRG neurons, and a pool of channels are localized to large dense-core vesicles (LDCV)-containing CGRP. We stimulated DRG neurons for CGRP release and found Slick channels contained within CGRP-positive LDCV translocated to the neuronal membrane. Behavioral studies in Slick knockout (KO) mice indicated increased basal heat detection and exacerbated thermal hyperalgesia compared with wild-type littermate controls during neuropathic and chronic inflammatory pain. Electrophysiologic recordings of DRG neurons from Slick KO mice revealed that Slick channels contribute to outward current, propensity to fire action potentials (APs), and to AP properties. Our data suggest that Slick channels restrain the excitability of CGRP-containing neurons, diminishing pain behavior after inflammation and injury.
机译：Slick（Kcnt2）钠激活钾（KNa）通道是快速门控且电压依赖性和钠依赖性钾通道，没有明确定义的生理功能。在背根神经节（DRGs）中，我们显示了光滑通道仅在包含降钙素基因相关肽（CGRP）的中小型降钙素神经元中表达，并且通道池位于大型密集核囊泡中（LDCV）包含的CGRP。我们刺激了DRG神经元的CGRP释放，并发现CGRP阳性LDCV中包含的平滑通道转移到了神经元膜。在Slick基因敲除（KO）小鼠中的行为研究表明，与野生型同窝仔对照相比，在神经性和慢性炎症性疼痛中，基础热检测增加，热痛觉过敏加剧。来自Slick KO小鼠的DRG神经元的电生理记录表明，Slick通道有助于外向电流，激发火势（AP）的倾向和AP特性。我们的数据表明，光滑通道可抑制含有CGRP的神经元的兴奋性，从而减少炎症和损伤后的疼痛行为。

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