...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Experimental Neuroscience >The Effect of Quercetin on Pro- and Anti-Inflammatory Cytokines in a Prenatally Stressed Rat Model of Febrile Seizures:
【24h】

The Effect of Quercetin on Pro- and Anti-Inflammatory Cytokines in a Prenatally Stressed Rat Model of Febrile Seizures:

机译：槲皮素对产前应激性高热惊厥大鼠模型中促炎和抗炎性细胞因子的影响：

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Febrile seizures are childhood convulsions resulting from an infection that leads to an inflammatory response and subsequent convulsions. Prenatal stress has been shown to heighten the progression and intensity of febrile seizures. Current medications are costly and have adverse effects associated with prolonged use. Quercetin flavonoid exhibits anti-inflammatory, anti-convulsant, and anti-stress effects. This study was aimed to investigate the therapeutic effect of quercetin in a prenatally stressed rat model of febrile seizures. We hypothesized that quercetin will alleviate the effects of prenatal stress in a febrile seizure rat model. On gestational day 13, Sprague-Dawley rat dams were subjected to restraint stress for 1?hour/d for 7?days. Febrile seizures were induced on postnatal day 14 on rat pups by intraperitoneally injecting lipopolysaccharide followed by kainic acid and quercetin on seizure onset. Hippocampal tissue was harvested to profile cytokine concentrations. Our results show that quercetin suppresses prenatal stress–induced pro-inflammatory marker (interleukin 1 beta) levels, subsequently attenuating febrile seizures. This shows that quercetin can be therapeutic for febrile seizures in prenatally stressed individuals.
机译：高热惊厥是儿童感染引起的抽搐，导致炎症反应和随后的抽搐。产前压力已显示出可加快发热性惊厥的进程和强度。当前的药物价格昂贵并且具有与长期使用相关的不利影响。槲皮素类黄酮具有抗炎，抗惊厥和抗应激作用。这项研究旨在调查槲皮素在产前应激性高热惊厥大鼠模型中的治疗作用。我们假设槲皮素将减轻高热惊厥大鼠模型中产前压力的影响。在妊娠第13天，对Sprague-Dawley大鼠大坝进行束缚压力1个小时/天，持续7天。在出生后的第14天，通过在幼鼠发作时腹膜内注射脂多糖，海藻酸和槲皮素诱导大鼠幼鼠出现高热惊厥。收获海马组织以分析细胞因子浓度。我们的结果表明，槲皮素抑制产前应激诱导的促炎性标志物（白介素1β）水平，从而减轻发热性癫痫发作。这表明槲皮素可以治疗产前紧张个体的高热惊厥。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号