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首页> 外文期刊>Journal of Experimental Neuroscience >Homeostatic Regulation of Interneuron Apoptosis During Cortical Development:
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Homeostatic Regulation of Interneuron Apoptosis During Cortical Development:

机译：皮质发育过程中神经元凋亡的稳态调节：

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The mammalian cortex consists of two main neuronal types: the principal excitatory pyramidal neurons (PNs) and the inhibitory interneurons (INs). The interplay between these two neuronal populations – which drive excitation and inhibition (E/I balance), respectively – is crucial for controlling the overall activity in the brain. A number of neurological and psychiatric disorders have been associated with changes in E/I balance. It is not surprising, therefore, that neural networks employ several different mechanisms to maintain their firing rates at a stable level, collectively referred as homeostatic forms of plasticity. Here, we share our views on how the size of IN populations may provide an early homeostatic checkpoint for controlling brain activity. In a recent paper published in Cell Reports, we demonstrate that the extent of IN apoptosis during a critical early postnatal period is plastic, cell type specific, and can be reduced in a cell-autonomous manner by acute increases in neuronal activity. We propose that a critical interplay between the physiological state of the network and its cellular units fine-tunes the size of IN populations with the aim of stabilizing network activity.
机译：哺乳动物皮层由两种主要的神经元类型组成：主要的兴奋性锥体神经元（PNs）和抑制性中间神经元（INs）。这两个神经元种群之间的相互作用（分别驱动兴奋和抑制（E / I平衡））对于控制大脑的整体活动至关重要。许多神经和精神疾病与E / I平衡的变化有关。因此，毫不奇怪，神经网络采用几种不同的机制将其射速保持在稳定的水平，统称为稳态形式的可塑性。在这里，我们就IN人口规模如何为控制脑部活动提供早期体内平衡检查点达成共识。在《细胞报告》上发表的最新论文中，我们证明了关键的出生后早期阶段IN凋亡的程度是可塑性的，是特定于细胞类型的，并且可以通过神经元活动的急剧增加以细胞自主的方式减少。我们建议网络的生理状态与其细胞单元之间的关键相互作用微调IN种群的大小，以稳定网络活动。

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