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Autophagy and its regulation by ginseng components

机译:人参成分自噬及其调控

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Autophagy is the sequential process whereby cell components are degraded, which can occur due to nutrient deprivation. Its regulation has an essential role in many diseases, functioning in both cell survival and cell death. Autophagy starts when mTORC1 is inhibited, resulting in the activation of several complexes to form a cargo that fuses with a lysosome, where it undergoes degradation. In this review, we describe a plant extract that is well known in Korea, namely Korean ginseng extract; we studied how its derivatives and metabolites can regulate autophagy and thus mediate the pathogenesis of certain diseases.
机译:自噬是细胞成分降解的顺序过程,这可能是由于营养缺乏引起的。它的调节在许多疾病中都起着至关重要的作用,在细胞存活和细胞死亡中起作用。自噬在抑制mTORC1时开始,导致多种复合物活化,形成与溶酶体融合的货物,并在其中降解。在本文中,我们描述了一种在韩国广为人知的植物提取物,即韩国人参提取物;我们研究了其衍生物和代谢产物如何调节自噬,从而介导某些疾病的发病机理。

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