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首页> 外文期刊>Journal of Gynecologic Oncology >Uterine metastases in ovarian carcinoma: frequency and survival in women who underwent hysterectomy
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Uterine metastases in ovarian carcinoma: frequency and survival in women who underwent hysterectomy

机译：卵巢癌的子宫转移：接受子宫切除术的女性的发生率和生存率

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Objective Possible reasons for hysterectomy in the initial surgical management of advanced invasive epithelial ovarian carcinoma (EOC) might be a high frequency of uterine involvement and its impact on survival. The aim of the present study was to describe the frequency of uterine involvement and its association with survival in an unselected population of EOC patients who underwent hysterectomy. Methods All incident cases of EOC diagnosed in Israeli Jewish women between March 1994 to June 1999, were identified within the framework of a nationwide case-control epidemiological study. The target population of the present report includes all stage II-IV EOC patients who had a uterus at the time of diagnosis. Of the 822 such patients, 695 fulfilled the inclusion criterion. Excluded were 141 patients for various reasons. The present analysis is based on the remaining 554 patients. Results Uterine involvement was present in 291 (52.5%) of the patients and it was macroscopic in only 78 (14.1%). The serosa was the most common site of isolated metastases. Multivariate analysis showed that advanced stage significantly increased the risk for uterine involvement. The overall median survival with any uterine involvement was significantly lower compared to those with no involvement (38.9 months vs. 58.0 months; p Conclusion There is an association between uterine involvement, whether macro- or microscopic, and lower survival even after hysterectomy although residual tumor could not be included in the analysis. Further studies are required to establish whether uterine involvement itself is an unfavorable risk factor or merely a marker of other unfavorable prognostic factors.
机译：目的在晚期浸润性上皮性卵巢癌（EOC）的初始手术管理中行子宫切除术的可能原因可能是子宫受累的频率高及其对生存的影响。本研究的目的是描述在子宫切除术的未选择的EOC患者群体中子宫受累的频率及其与生存的关系。方法在全国病例对照流行病学研究的框架内，确定1994年3月至1999年6月期间在以色列犹太妇女中诊断出的所有EOC事件。本报告的目标人群包括所有在诊断时患有子宫的II-IV期EOC患者。在822名此类患者中，有695名符合纳入标准。出于各种原因排除了141名患者。本分析基于剩余的554名患者。结果291例（52.5％）患者存在子宫受累，只有78例（14.1％）有肉眼观察。浆膜是最常见的孤立转移灶。多变量分析表明，晚期明显增加了子宫受累的风险。有子宫受累者的总中位生存期明显低于未受累者（38.9个月vs. 58.0个月; p结论子宫受累（无论是宏观还是微观）与较低的生存率之间存在相关性，即使子宫切除术后仍有残留肿瘤需要进行进一步的研究来确定子宫受累本身是不利的危险因素还是仅仅是其他不良预后因素的标志。

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