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首页> 外文期刊>Journal of Functional Biomaterials >Use of Micropatterned Thin Film Nitinol in Carotid Stents to Augment Embolic Protection
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Use of Micropatterned Thin Film Nitinol in Carotid Stents to Augment Embolic Protection

机译：微图案化薄膜镍钛合金在颈动脉支架中的应用以增强栓塞保护

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Stenting is an alternative to endarterectomy for the treatment of carotid artery stenosis. However, stenting is associated with a higher risk of procedural stroke secondary to distal thromboembolism. Hybrid stents with a micromesh layer have been proposed to address this complication. We developed a micropatterned thin film nitinol (M-TFN) covered stent designed to prevent thromboembolism during carotid intervention. This innovation may obviate the need or work synergistically with embolic protection devices. The proposed double layered stent is low-profile, thromboresistant, and covered with a M-TFN that can be fabricated with fenestrations of varying geometries and sizes. The M-TFN was created in multiple geometries, dimensions, and porosities by sputter deposition. The efficiency of various M-TFN to capture embolic particles was evaluated in different atherosclerotic carotid stenotic conditions through in vitro tests. The covered stent prevented emboli dislodgement in the range of 70%–96% during 30 min duration tests. In vitro vascular cell growth study results showed that endothelial cell elongation, alignment and growth behaviour silhouettes significantly enhance, specifically on the diamond-shape M-TFN, with the dimensions of 145 μm × 20 μm and a porosity of 32%. Future studies will require in vivo testing. Our results demonstrate that M-TFN has a promising potential for carotid artery stenting.
机译：支架术是动脉内膜切除术的替代方法，可用于治疗颈动脉狭窄。但是，支架置入术与继发于远端血栓栓塞的程序性卒中风险较高。已经提出了具有微孔层的混合支架以解决这种并发症。我们开发了一种微图案化的薄膜镍钛合金（M-TFN）覆盖的支架，旨在防止颈动脉介入治疗期间的血栓栓塞。该创新可以消除需求或与栓塞保护装置协同工作。所提出的双层支架是低轮廓的，抗血栓形成的，并覆盖有M-TFN，该M-TFN可以制造成具有不同几何形状和尺寸的窗孔。通过溅射沉积在多个几何形状，尺寸和孔隙率中创建了M-TFN。通过体外测试，在不同的动脉粥样硬化性颈动脉狭窄条件下评估了各种M-TFN捕获栓塞颗粒的效率。在30分钟的持续时间测试中，覆盖的支架可防止栓子脱落70％–96％。体外血管细胞生长研究结果表明，内皮细胞的伸长，排列和生长行为轮廓显着增强，特别是在菱形M-TFN上，尺寸为145μm×20μm，孔隙率为32％。未来的研究将需要体内测试。我们的结果表明，M-TFN在颈动脉支架置入方面具有广阔的发展潜力。

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