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首页> 外文期刊>Journal of Functional Biomaterials >Development of Phosphatized Calcium Carbonate Biominerals as Bioactive Bone Graft Substitute Materials, Part I: Incorporation of Magnesium and Strontium Ions
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Development of Phosphatized Calcium Carbonate Biominerals as Bioactive Bone Graft Substitute Materials, Part I: Incorporation of Magnesium and Strontium Ions

机译：磷酸化碳酸钙生物矿物质作为生物活性骨替代材料的开发，第一部分：镁和锶离子的掺入

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Synthetic materials based on calcium phosphate (CaP) are frequently used as bone graft substitutes when natural bone grafts are not available or not suitable. Chemical similarity to bone guarantees the biocompatibility of synthetic CaP materials, whereas macroporosity enables their integration into the natural bone tissue. To restore optimum mechanical performance after the grafting procedure, gradual resorption of CaP implants and simultaneous replacement by natural bone is desirable. Mg and Sr ions released from implants support osteointegration by stimulating bone formation. Furthermore, Sr ions counteract osteoporotic bone loss and reduce the probability of related fractures. The present study aimed at developing porous Ca carbonate biominerals into novel CaP-based, bioactive bone implant materials. Macroporous Ca carbonate biominerals, specifically skeletons of corals (aragonite) and sea urchins (Mg-substituted calcite), were hydrothermally converted into pseudomorphic CaP materials with their natural porosity preserved. Sr ions were introduced to the mineral replacement reactions by temporarily stabilizing them in the hydrothermal phosphate solutions as Sr-EDTA complexes. In this reaction system, Na, Mg, and Sr ions favored the formation of correspondingly substituted β-tricalcium phosphate over hydroxyapatite. Upon dissolution, the incorporated functional ions became released, endowing these CaP materials with bioactive and potentially osteoporotic properties.
机译：当天然骨移植物不可用或不合适时，基于磷酸钙（CaP）的合成材料通常用作骨移植物的替代品。与骨骼的化学相似性保证了合成CaP材料的生物相容性，而大孔使它们能够整合到天然骨骼组织中。为了在移植过程之后恢复最佳的机械性能，CaP植入物的逐渐吸收和同时被天然骨替代是理想的。植入物释放的Mg和Sr离子通过刺激骨骼形成来支持骨整合。此外，Sr离子可抵消骨质疏松性骨质流失并降低相关骨折的可能性。本研究旨在将多孔碳酸钙生物矿物质开发成新型的基于CaP的生物活性骨植入物材料。将大孔碳酸钙生物矿物，特别是珊瑚（文石）和海胆（镁取代的方解石）的骨架水热转化为假晶CaP材料，并保留其天然孔隙率。通过在水热磷酸盐溶液中将Sr离子作为Sr-EDTA络合物暂时稳定，从而将Sr离子引入矿物替代反应中。在该反应体系中，Na，Mg和Sr离子比羟基磷灰石有利于形成相应取代的β-磷酸三钙。溶解后，结合的功能离子被释放，使这些CaP材料具有生物活性和潜在的骨质疏松特性。

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