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首页> 外文期刊>Journal of Functional Biomaterials >Poly-L-lactic Acid (PLLA)-Chitosan-Collagen Electrospun Tube for Vascular Graft Application
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Poly-L-lactic Acid (PLLA)-Chitosan-Collagen Electrospun Tube for Vascular Graft Application

机译：聚-L-乳酸（PLLA）-壳聚糖-胶原电纺丝管在血管移植中的应用

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摘要

Poly-L-Lactic acid (PLLA) blended with chitosan and collagen was used to fabricate a conduit for blood vessel engineering through an electrospinning process. Various concentrations of chitosan were used in the blend in order to study its effect on the morphology, chemical bond, tensile strength, burst pressure, hemocompatibility, and cell viability (cytotoxicity) of the tube.In vitro assessments indicated that addition of chitosan-collagen could improve cell viability and hemocompatibility. Best results were demonstrated by the conduit with 10% PLLA, 0.5% chitosan, and 1% collagen. Tensile strength reached 2.13 MPa and burst pressure reached 2593 mmHg, both values that are within the range value of native blood vessel. A hemolysis percentage of 1.04% and a cell viability of 86.2% were obtained, meeting the standards of high hemocompatibility and low cytotoxicity for vascular graft material. The results are promising for further development toward vascular graft application.
机译：聚-L-乳酸（PLLA）与壳聚糖和胶原蛋白共混，用于通过电纺丝工艺制造用于血管工程的导管。共混物中使用了不同浓度的壳聚糖以研究其对试管的形态，化学键，抗张强度，破裂压力，血液相容性和细胞生存力（细胞毒性）的影响。体外评估表明，加入壳聚糖-胶原蛋白可以改善细胞活力和血液相容性。导管含10％PLLA，0.5％脱乙酰壳多糖和1％胶原蛋白的结果最好。拉伸强度达到2.13MPa，爆破压力达到2593mmHg，这两个值均在天然血管的范围内。获得的溶血百分比为1.04％，细胞活力为86.2％，符合血管移植材料的高血液相容性和低细胞毒性标准。该结果有望进一步推广到血管移植应用。

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