• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Experimental Neuroscience >Organization of Estrogen-Associated Circuits in the Mouse Primary Auditory Cortex:
【24h】

Organization of Estrogen-Associated Circuits in the Mouse Primary Auditory Cortex:

机译：小鼠初级听觉皮层中雌激素相关电路的组织：

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Sex steroid hormones influence the perceptual processing of sensory signals in vertebrates. In particular, decades of research have shown that circulating levels of estrogen correlate with hearing function. The mechanisms and sites of action supporting this sensory-neuroendocrine modulation, however, remain unknown. Here we combined a molecular cloning strategy, fluorescence in-situ hybridization and unbiased quantification methods to show that estrogen-producing and -sensitive neurons heavily populate the adult mouse primary auditory cortex (AI). We also show that auditory experience in freely-behaving animals engages estrogen-producing and -sensitive neurons in AI. These estrogen-associated networks are greatly stable, and do not quantitatively change as a result of acute episodes of sensory experience. We further demonstrate the neurochemical identity of estrogen-producing and estrogen-sensitive neurons in AI and show that these cell populations are phenotypically distinct. Our findings provide the first direct demonstration that estrogen-associated circuits are highly prevalent and engaged by sensory experience in the mouse auditory cortex, and suggest that previous correlations between estrogen levels and hearing function may be related to brain-generated hormone production. Finally, our findings suggest that estrogenic modulation may be a central component of the operational framework of central auditory networks.
机译：性类固醇激素影响脊椎动物感觉信号的感知过程。特别是，数十年的研究表明，雌激素的循环水平与听力功能相关。然而，支持这种感觉神经内分泌调节的机制和作用部位仍然未知。在这里，我们结合了分子克隆策略，荧光原位杂交和无偏定量方法，以显示雌激素产生和敏感神经元大量填充成年小鼠初级听觉皮层（AI）。我们还表明，在行为自由的动物中的听觉体验会在AI中产生雌激素和敏感神经元。这些与雌激素相关的网络非常稳定，并且不会因感觉经历的急性发作而发生定量变化。我们进一步证明AI中雌激素产生和雌激素敏感神经元的神经化学身份，并表明这些细胞群体在表型上是不同的。我们的发现提供了第一个直接的证明，即雌激素相关的回路在小鼠听觉皮层的感觉经验中非常普遍并且参与其中，并且表明雌激素水平和听力功能之间的先前相关性可能与脑生成激素的产生有关。最后，我们的发现表明雌激素调节可能是中央听觉网络运作框架的核心组成部分。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号