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首页> 外文期刊>Journal of Experimental Neuroscience >Attenuation of Methamphetamine-Induced conditioned place preference in Mice after a Drug-Free period and Facilitation of this effect by exposure to a Running Wheel:
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Attenuation of Methamphetamine-Induced conditioned place preference in Mice after a Drug-Free period and Facilitation of this effect by exposure to a Running Wheel:

机译：禁毒期后，甲基苯丙胺诱导的条件条件下的位置偏爱在小鼠中的减弱，并且通过暴露于跑步轮来促进这种效应：

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The effect of exposure of male mice to a horizontal running wheel (Fast-Trac?) on conditioned place preference (CPP) and hyperlocomotion induced by methamphetamine (METH) was determined. In the first experiment eleven-week-old male ICR mice were divided into three groups and exposed to three different environments (housed individually with (group A) or without a running wheel (group B), or housed in a group of eight mice without a running wheel (group C)) for two weeks except during periods of CPP conditioning and testing procedures. Administration of METH (0.5 mg/kg, i.p.) every other day during three conditioning sessions, with saline conditioning sessions in the other compartment on alternate days (ie, saline/METH conditioning), induced a significant CPP, compared to saline/saline conditioning, in mice of groups A and C, but not B. The increased CPP for METH was significantly attenuated by additional 5-day (drug-free)-exposure to a running wheel in mice of group A (but not group C). In the second experiment, pre-exposure of another set of mice to a running wheel for three days did not affect a subsequent METH (1.0 mg/kg)- or saline-induced horizontal locomotion or rearing, compared with the locomotor activities observed in mice without an experience of a running wheel. These observations suggest that experience of a running wheel may selectively facilitate an attenuation of drug-seeking behavior.
机译：确定了将雄性小鼠暴露于水平运行轮（Fast-Trac？）对甲基苯丙胺（METH）诱导的条件位置偏爱（CPP）和运动过度的影响。在第一个实验中，将11周大的ICR雄性小鼠分为三组，并暴露于三种不同的环境中（单独饲养（A组）或不带跑轮的饲养（B组），或饲养八只小鼠的组除CPP调节和测试程序期间外，连续两个星期（C组）。与盐水/生理盐水调理相比，在三个调理过程中每隔一天施用一次METH（0.5 mg / kg，ip），隔天在另一隔室进行生理盐水调理（即生理盐水/ METH调理），可产生显着的CPP。 ，在A和C组的小鼠中，但在B组没有。通过在A组（但不是C组）的小鼠的跑轮上额外进行5天（无毒）暴露，METH的CPP显着降低。在第二个实验中，与在小鼠中观察到的运动活动相比，将另一组小鼠预先暴露在运行轮中三天不会影响随后的METH（1.0 mg / kg）或盐水诱导的水平运动或饲养没有跑轮的经验。这些观察结果表明，运行轮的经历可以选择性地促进药物寻找行为的减弱。

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