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首页> 外文期刊>Journal of Hainan Medical University >The cerebral protective effect of mouse nerve growth factor combined with early mild hypothermia therapy for patients with severe craniocerebral injury and the influence on the inflammatory and stress reaction indexese
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The cerebral protective effect of mouse nerve growth factor combined with early mild hypothermia therapy for patients with severe craniocerebral injury and the influence on the inflammatory and stress reaction indexese

机译：小鼠神经生长因子联合早期亚低温治疗对重型颅脑损伤的脑保护作用及其对炎症和应激反应指标的影响

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Objective: To study the cerebral protective effect of mouse nerve growth factor combinedwith early mild hypothermia therapy for patients with severe craniocerebral injury and theinfluence on the inflammatory and stress reaction indexes. Methods: 68 patients with severecraniocerebral injury who were treated in our hospital between May 2012 and February2016 were collected and then divided into the control group (n=38) who received mildhypothermia therapy and the observation group (n=30) who received mouse nerve growthfactor combined with early mild hypothermia therapy after the treatment and laboratory testresults were reviewed. Immediately after admission and after 2 weeks of treatment, automaticbiochemical analyzer was used to detect the contents of nerve injury indexes; enzymelinkedimmunosorbent assay (ELISA) was used to detect the contents of neurotransmittersand inflammatory factors; RIA method was used to detect the contents of stress hormones.Results: Before treatment, the nerve injury indexes, neurotransmitters, inflammation factorsand stress hormones were not statistically different between two groups of patients (P0.05);after treatment, peripheral blood nerve function indexes myelin basic protein (MBP), ischemiamodified albumin (IMA) and neuron-specific enolase (NSE) levels of observation groupwere lower than those of control group while brain-derived neurotrophic factor (BDNF) levelwas higher than that of control group (P0.05); peripheral blood peptide neurotransmittersvasopressin (VAP), dynorphin (Dny-A) and neuropeptide (NPY) as well as amino acidneurotransmitters amino acid neurotransmitters glutamate (Glu) and aspartic acid (Asp)contents of observation group were lower than those of control group while γ-aminobutyricacid (GABA) level was higher than that of control group (P0.05); serum inflammatory factorsC-reactive protein (CRP), nuclear factor-κB (NF-κB) and interleukin-1β (IL-1β) contents aswell as stress hormones angiotensin II (AngII), cortisol (Cor), cortictrophin-releasing hormone(CRH) and norepinephrine (NE) contents of observation group were lower than those ofcontrol group (P0.05). Conclusion: Mouse nerve growth factor combined with early mildhypothermia therapy can protect the brain function and inhibit the systemic inflammatory andstress reaction in patients with severe craniocerebral injury.
机译：目的：研究小鼠神经生长因子联合早期亚低温治疗对重型颅脑损伤的保护作用及其对炎症和应激反应指标的影响。方法：收集2012年5月至2016年2月在我院收治的68例重度颅脑损伤患者，分为亚低温治疗的对照组（n = 38）和接受小鼠神经生长因子的观察组（n = 30）。回顾了治疗后联合早期轻度亚低温治疗和实验室检查结果。入院后及治疗2周后，立即用自动生化分析仪检测神经损伤指标的含量。用酶联免疫吸附法（ELISA）检测神经递质和炎症因子的含量。结果：治疗前两组患者的神经损伤指标，神经递质，炎症因子和应激激素无统计学差异（P> 0.05）;治疗后外周血神经功能无统计学意义（P> 0.05）。观察组的髓鞘碱性蛋白（MBP），缺血修饰白蛋白（IMA）和神经元特异性烯醇化酶（NSE）水平低于对照组，而脑源性神经营养因子（BDNF）水平高于对照组（P < 0.05）;观察组患者外周血肽神经递质血管加压素（VAP），强啡肽（Dny-A）和神经肽（NPY）以及氨基酸神经递质谷氨酸（Glu）和天冬氨酸（Asp）的含量均低于对照组，而γ -氨基丁酸（GABA）水平高于对照组（P <0.05）;血清炎症因子C反应蛋白（CRP），核因子-κB（NF-κB）和白介素1β（IL-1β）的含量以及应激激素血管紧张素II（AngII），皮质醇（Cor），促肾上腺皮质激素释放激素（CRH） ），观察组去甲肾上腺素（NE）含量均低于对照组（P <0.05）。结论：小鼠神经生长因子联合早期亚低温治疗可以保护重型颅脑损伤患者的脑功能并抑制全身炎症反应和应激反应。

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