CONSTRUCTION OF GOLD NANORODS CARRYING IFNγ AND METHIONINE TO TARGET MCF-7 CELLS

R. Farhoudi; M. Ghorbani

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CONSTRUCTION OF GOLD NANORODS CARRYING IFNγ AND METHIONINE TO TARGET MCF-7 CELLS

机译：携带IFNγ和蛋氨酸的金纳米颗粒靶向MCF-7细胞的构建

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Development of gold nanoparticles (GNPs) conjugated with interferon gamma (IFNγ) and methionine along with the use of near-infrared (NIR) laser beams for treatment of cancer cells was the main aim of this study. MCF-7 cells were cultured and incubated with conjugated GNPs with IFNγ and methionine at different concentration followed by irradiation with NIR laser beam. Samples were then evaluated for their viability by MTT assay which showed that the GNPs complex was toxic on tumor cells (P0.05) at 0.64μg/ml concentration. Exposure to hyperthermia decreased the viability of cells significantly at 0.3μg/ml concentration of gold nanorods complex.

机译：本研究的主要目的是开发与干扰素γ（IFNγ）和蛋氨酸结合的金纳米颗粒（GNP）以及使用近红外（NIR）激光束治疗癌细胞。培养MCF-7细胞，并与缀合有不同浓度的IFNγ和蛋氨酸的GNP一起温育，然后用NIR激光束照射。然后通过MTT测定评估样品的生存力，该测定表明GNP复合物以0.64μg/ ml的浓度对肿瘤细胞有毒性（P ＜0.05）。在金纳米棒复合物浓度为0.3μg/ ml的情况下，暴露于高温会显着降低细胞活力。

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《Digest Journal of Nanomaterials and Biostructures》 |2018年第1期|共10页
作者
R. Farhoudi; M. Ghorbani;
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中图分类生物科学;
关键词
Hyperthermiagold nanorodsMCF-7NIR laserinterferon -gamma.;

机译：Hyperthermiagold纳米棒MCF-7NIR激光干扰素-γ。;

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CONSTRUCTION OF GOLD NANORODS CARRYING IFNγ AND METHIONINE TO TARGET MCF-7 CELLS

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