...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of immunology research. >Suppression of Th17 Cell Response in the Alleviation of Dextran Sulfate Sodium-Induced Colitis by Ganoderma lucidum Polysaccharides
【24h】

Suppression of Th17 Cell Response in the Alleviation of Dextran Sulfate Sodium-Induced Colitis by Ganoderma lucidum Polysaccharides

机译：灵芝多糖减轻硫酸葡聚糖硫酸钠诱导的结肠炎Th17细胞反应的抑制。

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background. Ganoderma lucidum polysaccharides (GLP) has anti-inflammatory and immunomodulatory effects. Dysregulated immune responses are involved in the pathogenesis of dextran sulfate sodium (DSS)-induced colitis. The aim of this study was to assess the therapeutic potential of GLP to alleviate DSS-induced colitis. Methods. The mice were administered with GLP by intragastric gavage daily for two weeks prior to the DSS treatment. Mice were orally administered with 2.5% DSS dissolved in drinking water with GLP or water treatment for 6 days. The mice were killed on day 7 after induction of colitis. Survival rates, body weight loss, colon lengths, histological changes, and disease activity index scores (DAI) were evaluated. Results. GLP significantly improved survival rates, colon length shortening, body weight loss, histopathological score, and DAI scores in mice with DSS-induced colitis. GLP markedly suppressed the secretions of TNF-α, IL-1β, IL-6, IL-17A, and IL-4 and significantly affected populations of Th17 cells, B cells, NK cells, and NKT cells in the lamina propria lymphocytes. Conclusions. GLP prevented inflammation, maintained intestinal homeostasis, and regulated the intestinal immunological barrier functions in mice with DSS-induced colitis.
机译：背景。灵芝多糖（GLP）具有抗炎和免疫调节作用。免疫反应失调与硫酸葡聚糖硫酸钠（DSS）引起的结肠炎的发病机理有关。这项研究的目的是评估GLP缓解DSS诱发的结肠炎的治疗潜力。方法。在DSS治疗之前，每天通过胃内灌胃法给小鼠施用GLP，持续两周。用GLP或水处理对小鼠口服给予溶于饮用水的2.5％DSS，持续6天。在诱导结肠炎后第7天将小鼠处死。评估存活率，体重减轻，结肠长度，组织学变化和疾病活动性指数评分（DAI）。结果。 GLP可以显着改善DSS诱发的结肠炎小鼠的存活率，缩短结肠长度，减轻体重，组织病理学评分和DAI评分。 GLP显着抑制了TNF-α，IL-1β，IL-6，IL-17A和IL-4的分泌，并显着影响了固有层淋巴细胞中Th17细胞，B细胞，NK细胞和NKT细胞的种群。结论。 GLP预防了DSS诱发的结肠炎小鼠的炎症反应，维持了肠道的稳态，并调节了肠道的免疫屏障功能。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号