All-Trans Retinoic Acid Induces CD4

Xiaohong Sun; Yangfan Xiao; Zhuotong Zeng; Yaqian Shi; Bingsi Tang; Hai Long; Takuro Kanekura; Jiucun Wang; Haijing Wu; Ming Zhao; Qianjin Lu; Rong Xiao

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All-Trans Retinoic Acid Induces CD4

机译：全反式维甲酸诱导CD4

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Background. Retinoic acid (RA) is an active metabolite of vitamin A and has been reported to improve the clinical symptoms of patients with systemic sclerosis (SSc). However, the mechanism of RA in the prevention of SSc remains unclear. Regulatory T cells (Tregs) are a subpopulation of T cells with immunosuppressive activity. The quantitative and functional defects of Tregs may mediate the immune dysfunction in SSc. The addition of all-trans retinoic acid (ATRA) to human naïve CD4

机译：背景。维甲酸（RA）是维生素A的活性代谢产物，据报道可改善系统性硬化症（SSc）患者的临床症状。但是，RA预防SSc的机制仍不清楚。调节性T细胞（Tregs）是具有免疫抑制活性的T细胞亚群。 Treg的数量和功能缺陷可能介导SSc的免疫功能障碍。在人类幼稚CD4中添加全反式维甲酸（ATRA）

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《Journal of immunology research.》 |2018年第2期|共页
作者
Xiaohong Sun; Yangfan Xiao; Zhuotong Zeng; Yaqian Shi; Bingsi Tang; Hai Long; Takuro Kanekura; Jiucun Wang; Haijing Wu; Ming Zhao; Qianjin Lu; Rong Xiao;
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中图分类免疫性疾病;
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1. All-Trans Retinoic Acid Induces CD4+CD25+FOXP3+ Regulatory T Cells by Increasing FOXP3 Demethylation in Systemic Sclerosis CD4+ T Cells [J] . Xiaohong Sun, Yangfan Xiao, Zhuotong Zeng, Clinical & developmental immunology. . 2018,第1期

机译：通过在全身硬化CD4 + T细胞中增加Foxp3去甲基化，全反式视黄酸诱导CD4 + CD25 + Foxp3 +调节T细胞
2. All-Trans Retinoic Acid Induces CD4 [J] . Xiaohong Sun, Yangfan Xiao, Zhuotong Zeng, Journal of immunology research. . 2018,第1期

机译：全反式维甲酸诱导CD4
3. CD4+ Foxp3+ regulatory T cells induced by TGF-beta, IL-2 and all-trans retinoic acid attenuate obliterative bronchiolitis in rat trachea transplantation. [J] . Shi Q, Cao H, Liu J, International immunopharmacology . 2011,第11期

机译：TGF-β，IL-2和全反式维甲酸诱导的CD4 + Foxp3 +调节性T细胞在大鼠气管移植中减弱了闭塞性细支气管炎。
4. The Antitumor Effects of All-Trans Retinoic Acid-loaded Dendermers against Human Hepatocarcinoma Cells [C] . Congcong Liu, Linshuang Qi, Yongjian Wang World biomaterials congress . 2012

机译：全反式维甲酸负载的弯曲剂对人肝癌细胞的抗肿瘤作用
5. Development and characterization of polymer-oil nanostructured carrier (PONC) for controlled delivery of all-trans retinoic acid (ATRA). [D] . Narvekar, Mayuri M. 2014

机译：聚合物-油纳米结构载体（PONC）的开发和表征，用于全反式视黄酸（ATRA）的受控输送。
6. All-Trans Retinoic Acid Induces CD4+CD25+FOXP3+ Regulatory T Cells by Increasing FOXP3 Demethylation in Systemic Sclerosis CD4+ T Cells [O] . Xiaohong Sun, Yangfan Xiao, Zhuotong Zeng, 2018

机译：全反式维甲酸通过增加系统性硬化症CD4 + T细胞中的FOXP3去甲基化诱导CD4 + CD25 + FOXP3 +调节性T细胞。
7. Novel retinoic acid, 9-cis retinoic acid, in combination with all-trans retinoic acid is an effective inducer of differentiation of retinoic acid-resistant HL-60 cells [O] . M Kizaki, H Nakajima, S Mori, 1994

机译：新型视黄酸，9-顺式维甲酸，与全反式视黄酸组合是有效的视黄酸抗性HL-60细胞分化的有效诱导剂

All-Trans Retinoic Acid Induces CD4

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