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首页> 外文期刊>Journal of Hainan Medical University >Differences in ultrasonography parameters of benign and malignant thyroid nodules and their correlation with angiogenesis and cell proliferation within the lesions
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Differences in ultrasonography parameters of benign and malignant thyroid nodules and their correlation with angiogenesis and cell proliferation within the lesions

机译：甲状腺良恶性结节的超声参数差异及其与病变内血管生成和细胞增殖的关系

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Objective: To investigate the differences in ultrasonography parameters of benign and malignant thyroid nodules and their correlation with angiogenesis and cell proliferation within the lesions. Methods: A total of 178 patients with thyroid nodules who were screened in this hospital between August 2015 and October 2017 were divided into benign thyroid nodule group (n=146) and thyroid carcinoma group (n=32) according to pathological examination via fine needle aspiration. Two groups of patients received ultrasonography to obtain the relevant parameters, the fluorescence quantitative PCR method was used to detect the expression of genes related to angiogenesis and cell proliferation, and Pearson test was used to evaluate the correlation between thyroid cancer ultrasonography parameters and malignant molecule expression. Results: AUC and Peak levels in thyroid carcinoma group were lower than those in benign thyroid nodule group; angiogenesis-related genes HIF-1 毩 , VEGF, TTF-1, MMP-9 and COX-2 mRNA expression were higher than those in benign thyroid nodule group; cell proliferation-related genes AG490, CCNG2, PP4R1 and TBB mRNA expression were lower than those in benign thyroid nodule group whereas BRD4 and TPX2 mRNA expression were higher than those in benign thyroid nodule group. Pearson test showed that the lesion ultrasonography parameters AUC and Peak levels in patients with thyroid cancer were directly correlated with the expression of genes related to angiogenesis and cancer cell proliferation. Conclusions: The ultrasonography parameter levels of thyroid cancer lesion are abnormal, and the specific abnormal degree is directly correlated with tumor angiogenesis and cell proliferation.
机译：目的：探讨甲状腺良恶性结节的超声检查参数差异及其与病变内血管生成和细胞增殖的关系。方法：2015年8月至2017年10月在我院筛查的178例甲状腺结节患者，经细针病理检查分为良性甲状腺结节组（146例）和甲状腺癌组（32例）。愿望。两组患者均接受超声检查以获取相关参数，采用荧光定量PCR方法检测与血管生成和细胞增殖相关的基因表达，并采用Pearson检验评价甲状腺癌超声参数与恶性分子表达之间的相关性。 。结果：甲状腺癌组的AUC和峰值水平均低于良性甲状腺结节组。血管生成相关基因HIF-1毩，VEGF，TTF-1，MMP-9和COX-2 mRNA的表达高于甲状腺良性结节组。细胞增殖相关基因AG490，CCNG2，PP4R1和TBB mRNA的表达低于良性甲状腺结节组，而BRD4和TPX2 mRNA的表达高于良性甲状腺结节组。皮尔逊检验表明，甲状腺癌患者的病变超声检查参数AUC和峰值水平与与血管生成和癌细胞增殖相关的基因表达直接相关。结论：甲状腺癌病灶超声参数水平异常，其具体异常程度与肿瘤血管生成和细胞增殖直接相关。

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