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首页> 外文期刊>Journal of health, population, and nutrition >Perinatal Outcomes of Multiple Births in Southwest Nigeria
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Perinatal Outcomes of Multiple Births in Southwest Nigeria

机译：尼日利亚西南部多胎的围产期结局

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Compared to singletons, multiple births are associated with a substantially-higher risk of maternal and perinatal mortality worldwide. However, little evidence exists on the perinatal profile and risk of neurodevelopmental disabilities among the survivors, especially in developing countries. This cross-sectional study, therefore, set out to determine the adverse perinatal outcomes that are potential markers for neurodevelopmental disabilities in infants with multiple gestations in a developing country. In total, 4,573 mothers, and their 4,718 surviving offspring in an inner-city maternity hospital in Lagos, Nigeria, from May 2005 to December 2007, were recruited. Comparisons of maternal and infant outcomes between single and multiple births were performed using multivariable logistic regression and generalized estimation equation analyses. Odds ratio (OR) and the corresponding 95% confidence interval (CI) for each marker were estimated. Of the 4,573 deliveries, there were 4,416 (96.6%) singletons and 157 (3.4%) multiples, comprising 296 twins and six triplets together (6.4% of all live 4,718 infants). After adjusting for maternal age, ethnicity, occupation, parity, and antenatal care, multiple gestations were associated with increased risks of hypertensive disorders and caesarean delivery. Similarly, after adjusting for potential maternal confounders, multiple births were associated with low five-minute Apgar score (OR: 1.47, 95% CI 1.13-1.93), neonatal sepsis (OR: 2.16, 95% CI 1.28-3.65), severe hyperbilirubinaemia (OR: 1.60, 95% CI 1.00-2.56), and admission to a special-care baby unit (OR: 1.56, 95% CI 1.12-2.17) underpinned by preterm delivery before 34 weeks (OR: 1.91, 95% CI 1.14-3.19), birthweight of less than 2,500 g (OR: 6.45, 95% CI 4.80-8.66), and intrauterine growth restriction (OR: 9.04, 95% CI 6.62-12.34). Overall, the results suggest that, in resource-poor settings, infants of multiple gestations are associated with a significantly-elevated risk of adverse perinatal outcomes. Since these perinatal outcomes are related to the increased risk of later neurodevelopmental disabilities, multiple-birth infants merit close developmental surveillance for timely intervention.
机译：与单胎相比，多胎与全世界产妇和围产儿死亡的风险高得多有关。但是，关于幸存者的围产期概况和神经发育障碍风险的证据很少，特别是在发展中国家。因此，这项横断面研究旨在确定不良的围产期结局，这些结局是发展中国家多胎婴儿神经发育障碍的潜在标志。从2005年5月至2007年12月，在尼日利亚拉各斯的一家市区妇产医院，总共招募了4,573名母亲及其4,718名存活的后代。使用多变量逻辑回归和广义估计方程分析对单胎和多胎之间的母婴结局进行比较。估计每个标记的赔率（OR）和相应的95％置信区间（CI）。在4,573例分娩中，有4,416（96.6％）个单胎和157个（3.4％）的倍数，包括296对双胞胎和6个三胞胎（占所有4,718名婴儿的6.4％）。在调整了产妇的年龄，种族，职业，均等和产前护理后，多胎妊娠与高血压疾病和剖腹产的风险增加有关。同样，在调整了潜在的产妇混杂因素之后，多胎与五分钟Apgar评分低（OR：1.47，95％CI 1.13-1.93），新生儿败血症（OR：2.16，95％CI 1.28-3.65），严重高胆红素血症有关（OR：1.60，95％CI 1.00-2.56），并进入特殊护理婴儿病房（OR：1.56，95％CI 1.12-2.17），并在34周前早产来支持（OR：1.91，95％CI 1.14） -3.19），出生体重不足2500克（OR：6.45、95％CI 4.80-8.66）和宫内生长受限（OR：9.04，95％CI 6.62-12.34）。总体而言，结果表明，在资源匮乏的环境中，多胎婴儿与不良围生期结局的风险显着升高有关。由于这些围产期结局与后来神经发育障碍的风险增加有关，因此多产婴儿应密切监测发育情况，以便及时干预。

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