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首页> 外文期刊>Journal of Hainan Medical University >Influence of propofol or etomidate combined with remifentanil in painless gastroscopy on inflammatory stress response
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Influence of propofol or etomidate combined with remifentanil in painless gastroscopy on inflammatory stress response

机译：丙泊酚或依托咪酯联合瑞芬太尼在无痛胃镜检查中对炎症应激反应的影响

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Objective: To study the influence of propofol or etomidate combined with remifentanil in painless gastroscopy on inflammatory stress response. Methods: 117 patients with suspected gastritis who underwent painless gastroscopy in our hospital between July 2015 and August 2016 were divided into propofol group (n=67) and etomidate group (n=50) according to the anesthesia schemes. Propofol group received propofol combined with remifentanil anesthesia, and etomidate group received etomidate combined with remifentanil anesthesia. The differences in serum levels of inflammatory factors, stress hormones and oxidative stress indicators were compared between the two groups before the examination (T0), immediately after the examination (T1) and 15 min after the examination (T2). Results: At T0, there were no significant differences in serum levels of inflammatory factors, stress hormones or oxidative stress indexes between the two groups (P0.05). At T1 and T2, serum inflammatory factors IL-1, IL-6 and CRP levels of etomidate group were lower than those of propofol group; serum stress hormones Cor, NE and E levels were lower than those of propofol group; serum oxidation indexes AOPPs and LHP levels were lower than those of propofol group while anti- oxidation indexes CAT and SOD levels were higher than those of propofol group (P0.05). Conclusion: Etomidate for painless gastroscopy is better than propofol in maintaining depth of anesthesia and reducing operation trauma.
机译：目的：研究丙泊酚或依托咪酯联合瑞芬太尼在无痛胃镜检查中对炎症应激反应的影响。方法：根据麻醉方案，将2015年7月至2016年8月在我院接受无痛胃镜检查的117例可疑胃炎患者分为丙泊酚组（n = 67）和依托咪酯组（n = 50）。丙泊酚组接受丙泊酚联合瑞芬太尼麻醉，依托咪酯组接受依托咪酯联合瑞芬太尼麻醉。比较两组在检查前（T0），检查后立即（T1）和检查后15分钟（T2）的血清炎症因子，应激激素和氧化应激指标水平的差异。结果：在T0时，两组的血清炎症因子，应激激素或氧化应激指标水平无显着差异（P> 0.05）。在T1和T2，依托咪酯组的血清炎性因子IL-1，IL-6和CRP水平低于丙泊酚组。血清应激激素Cor，NE和E水平低于丙泊酚组;血清氧化指标AOPPs和LHP水平低于丙泊酚组，而抗氧化指标CAT和SOD水平高于丙泊酚组（P <0.05）。结论：依托咪酯无痛胃镜在维持麻醉深度和减少手术创伤方面优于丙泊酚。

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