...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Global Health >National and subnational estimation of the prevalence of peripheral artery disease (PAD) in China: a systematic review and meta-analysis
【24h】

National and subnational estimation of the prevalence of peripheral artery disease (PAD) in China: a systematic review and meta-analysis

机译：国家和国家以下地区对中国外周动脉疾病（PAD）患病率的估计：系统评价和荟萃分析

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background Peripheral artery disease (PAD), the third leading cause of atherosclerotic vascular morbidity, affects approximately 202 million people worldwide, among whom more than two-thirds reside in low- and middle-income countries (LMIC). For China, the largest developing country, little is known about the epidemiology of PAD. We aimed to estimate the prevalence of PAD and the number of affected people in China, establish the main risk factors for PAD and assess the number of people with PAD at the sub-national level. Methods We searched China National Knowledge Infrastructure (CNKI), Wanfang, Chinese Biomedicine Literature Database (CBM-SinoMed), PubMed, Embase and Medline for population-based studies that have reported the prevalence of PAD in the general Chinese population from 1990 onwards. PAD was defined as an ankle-brachial index (ABI) lower than or equal to 0.90. We used a multilevel mixed-effects logistic regression to generate the gender- and age-specific prevalence of PAD, and a random-effects meta-analysis to pool the odds ratios (ORs) of major risk factors. United Nations population numbers were used to estimate and project the number of affected people from 2000 to 2020. Finally, we used the risk factors-based model to distribute the national number of people with PAD into different settings (urban and rural) and regions (East, Central and West) for the year 2010. Results Overall, 37 articles met all inclusion criteria and provided prevalence estimates, among which 14 also explored risk factors for PAD. The prevalence of PAD increased gradually by age until mid-60s, after which the increase accelerated. In males, the prevalence of PAD ranged from 2.81% (95% CI?=?1.77-4.43) in those aged 25-29 years to 21.95% (95% CI?=?15.39-30.31) in those 95-99 years old. In females, the PAD prevalence increased from 3.84% (95% CI?=?2.44-5.98) in those aged 25-29 years to 27.95% (95% CI?=?20.14-37.37) in those aged 95-99 years. The PAD prevalence was consistently higher in females than in males across all age groups. This difference was most significantly pronounced among the elderly, starting from 60 years. Between 2000 and 2020, the total number of Chinese people with PAD is expected to increase by 40%: from 29.44 million (95% CI?=?22.51-38.62) in 2000 to 41.13 million (95% CI?=?32.00-52.95) in 2020. Current smoking was the strongest risk factor for PAD, with a meta-odds ratio (OR) of 2.62 (95% CI?=?1.44-4.76), followed by hypertension (1.94, 95% CI?=?1.48-2.53) and diabetes (1.71, 95% CI?=?1.45-2.01). In 2010, 15.18 million (95% CI?=?11.74-19.67) people with PAD resided in the East China, 11.08 million (95% CI?=?8.61-14.28) in the Central China and 8.65 million (95% CI?=?6.71-11.16) in the West China. In addition, 24.20 million (95% CI?=?18.82-31.16) people with PAD were living in rural areas, accounting for almost 70% of all PAD cases in China. Conclusions With rapid ageing in China, PAD has become a serious public health problem. More research and optimal interventions on PAD are required to better identify effective strategies for prevention and treatment of PAD in China.
机译：背景技术外周动脉疾病（PAD）是动脉粥样硬化血管发病的第三大主要原因，在全世界范围内影响着2.02亿人，其中三分之二以上居住在中低收入国家（LMIC）。对于最大的发展中国家中国，对PAD的流行病学知之甚少。我们的目的是估计中国PAD的患病率和受影响人数，确定PAD的主要风险因素，并在地方一级评估PAD的人数。方法我们搜索了中国国家知识基础设施（CNKI），万方，中国生物医学文献数据库（CBM-SinoMed），PubMed，Embase和Medline，进行基于人群的研究，这些研究报告了1990年以来中国普通人群中PAD的患病率。 PAD被定义为低于或等于0.90的踝肱指数（ABI）。我们使用了多层次的混合效应逻辑回归来生成PAD的性别和年龄特定患病率，并使用随机效应荟萃分析汇总了主要危险因素的比值比（OR）。联合国人口数量用于估计和预测2000年至2020年的受影响人口。最后，我们使用基于风险因素的模型将全国PAD人口分布到不同的环境（城市和农村）和地区（ （东部，中部和西部）2010年。结果总体上，共有37篇文章符合所有纳入标准并提供了患病率估算，其中14篇还探讨了PAD的危险因素。 PAD的患病率随年龄增长逐渐增加，直至60年代中期，此后增长加快。在男性中，PAD的患病率介于25-29岁年龄段的2.81％（95％CI？=？1.77-4.43）到95-99岁年龄段的21.95％（95％CI？=？15.39-30.31）。 。女性的PAD患病率从25-29岁年龄段的3.84％（95％CI？=？2.44-5.98）上升到95-99岁年龄段的27.95％（95％CI？=？20.14-37.37）。在所有年龄段中，女性的PAD患病率始终高于男性。从60岁开始，这种差异在老年人中最为明显。从2000年到2020年，中国患有PAD的人数预计将增长40％：从2000年的2944万（95％CI？= 22.51-38.62）增加到4113万（95％CI = 32.00-52.95） ）的吸烟率是2020年的最高水平。目前吸烟是PAD的最强危险因素，其元比（OR）为2.62（95％CI？= 1.44-4.76），其次是高血压（1.94，95％CI？= 1.48） -2.53）和糖尿病（1.71，95％CI≥1.45-2.01）。 2010年，华东地区有1,518万（95％CI？=？11.74-19.67）PAD人;华中地区有1,108万人（95％CI？=？8.61-14.28）; 865万（中国95％CI？）。 =？6.71-11.16）。此外，有2420万（95％CI =？18.82-31.16）PAD患者生活在农村地区，几乎占中国所有PAD病例的70％。结论随着中国的快速老龄化，PAD已成为一个严重的公共卫生问题。为了更好地确定中国预防和治疗PAD的有效策略，需要对PAD进行更多的研究和最佳干预。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号