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首页> 外文期刊>Journal of Hainan Medical University >Influence of pidotimod combined with conventional drug therapy on the infection status and immune function of children with recurrent respiratory tract infection
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Influence of pidotimod combined with conventional drug therapy on the infection status and immune function of children with recurrent respiratory tract infection

机译：匹多莫德联合常规药物治疗对反复呼吸道感染儿童感染状况和免疫功能的影响

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Objective: To study the influence of pidotimod combined with conventional drug therapy onthe infection status and immune function of children with recurrent respiratory tract infection.Methods: A total of 118 children with recurrent respiratory tract infection who were treated inthe hospital between January 2015 and January 2017 were collected and divided into controlgroup and observation group by random number table method, 59 cases in each group. Controlgroup received conventional therapy, and observation group received pidotimod combinedwith conventional therapy. The differences in serum levels of inflammatory mediators, acutephase proteins and Th1/Th2 cytokines were compared between the two groups before andafter treatment. Results: Before treatment, the differences in serum levels of inflammatorymediators, acute phase proteins and Th1/Th2 cytokines were not statistically significantbetween the two groups. after 1 week of treatment, serum TNF-α, PCT, CRP, PAB, TRFand IL-4 contents of both groups of children were lower than those before treatment whileIFN-γ contents as well as IFN-γ/ IL-4 levels were higher than those before treatment, andserum TNF-α, PCT, CRP, PAB, TRF and IL-4 contents of observation group were lower thanthose of control group while IFN-γ content as well as IFN-γ/ IL-4 level was higher thanthose of control group. Conclusion: Pidotimod combined with conventional drug therapy caneffectively inhibit the infection status and optimize the Th1/Th2 cellular immune function ofchildren with recurrent respiratory tract infection.
机译：目的：研究吡吡莫德联合常规药物治疗对复发性呼吸道感染儿童感染状态和免疫功能的影响。方法：2015年1月至2017年1月在医院接受治疗的118例复发性呼吸道感染儿童随机数字表法将其分为对照组和观察组，每组59例。对照组接受常规治疗，观察组接受匹多莫德联合常规治疗。比较两组治疗前后血清炎症介质，急性期蛋白和Th1 / Th2细胞因子的水平差异。结果：两组患者治疗前血清炎症介质，急性期蛋白和Th1 / Th2细胞因子水平差异无统计学意义。治疗1周后，两组患儿的血清TNF-α，PCT，CRP，PAB，TRF和IL-4含量均低于治疗前，而IFN-γ含量以及IFN-γ/ IL-4水平较高观察组的血清TNF-α，PCT，CRP，PAB，TRF和IL-4含量均比治疗前低，而IFN-γ含量以及IFN-γ/ IL-4水平均高于对照组。对照组。结论：吡多莫德联合常规药物治疗可有效抑制反复呼吸道感染儿童的感染状况，并优化其Th1 / Th2细胞免疫功能。

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