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首页> 外文期刊>Journal of infection and public health. >Transfusion transmitted infections in frequently transfused thalassemic children living in Fayoum Governorate, Egypt: Current prevalence and risk factors
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Transfusion transmitted infections in frequently transfused thalassemic children living in Fayoum Governorate, Egypt: Current prevalence and risk factors

机译：埃及法尤姆省经常输血的地中海贫血儿童的输血传播感染：目前的流行率和危险因素

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Regular blood transfusion therapy remains the primary treatment in thalassemia major (TM). Transfusion-transmitted infections (TTIs) and iron overload are considered to be the major drawbacks of this therapy. This cross-sectional study aimed to update the prevalence of the hepatitis C virus (HCV) antibody, PCR-confirmed HCV, hepatitis B surface antigen (HBsAg), and human immunodeficiency virus (HIV) antibody among TM children. Clinical and epidemiological factors that can affect HCV infection prevalence rate were studied. This study evaluated 121 children with @bTM, including 61 males and 60 females with a mean age of 7.99+/-3.57years. Patients were evaluated for the HCV, HBsAg, and HIV-1 & 2 antibodies. All tests were performed using ELISA. HCV positive cases were confirmed by RT-PCR. Twenty-five patients were positive for the HCV antibody (20.7%); 22 were confirmed positive by PCR. Six patients (5%) were HBsAg-positive. No patients were HIV-positive. Older age were associated with an increased frequency of HCV positive infection (P =10 times/year, and older age, >=10years, were reported as predictors of HCV infection (P=0.018 and 0.011, respectively). A significant association of HCV between HBV infections was reported (P value=0.01). There was no significant effect of the pre-transfusion or post-transfusion hemoglobin level on the frequency of HCV positive cases. HCV still represents a major health challenge for frequently transfused Egyptian patients. The prevalence rate of HBV infection remains relatively high. Therefore, it is necessary to implement measures to improve blood transfusion screening.
机译：常规输血疗法仍然是重型地中海贫血（TM）的主要治疗方法。输血传播感染（TTI）和铁超载被认为是该疗法的主要缺点。这项横断面研究旨在更新TM儿童中丙型肝炎病毒（HCV）抗体，PCR确认的HCV，乙型肝炎表面抗原（HBsAg）和人免疫缺陷病毒（HIV）抗体的患病率。研究了影响HCV感染率的临床和流行病学因素。这项研究评估了121名患有@bTM的儿童，包括61名男性和60名女性，平均年龄为7.99 +/- 3.57岁。对患者进行了HCV，HBsAg和HIV-1和2抗体评估。所有测试均使用ELISA进行。 HCV阳性病例通过RT-PCR确认。 25例HCV抗体阳性（20.7％）;通过PCR确认22个阳性。六例（5％）HBsAg阳性。没有患者是艾滋病毒阳性。年龄越大，HCV阳性感染的频率越高（P = 10次/年，而年龄≥10岁，据报道是HCV感染的预测因子（分别为P = 0.018和0.011）。据报道，HBV感染之间存在差异（P值= 0.01），输血前或输血后血红蛋白水平对HCV阳性病例的频率没有显着影响，但HCV仍是埃及经常输血患者面临的主要健康挑战。 HBV感染的流行率仍然较高，因此有必要采取措施改善输血筛查。

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