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首页> 外文期刊>Journal of Indian Academy of Oral Medicine and Radiology >Expression of cyclin D1 in oral squamous cell carcinoma and its correlation with histological differentiation: An immunohistochemical study
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Expression of cyclin D1 in oral squamous cell carcinoma and its correlation with histological differentiation: An immunohistochemical study

机译：cyclin D1在口腔鳞状细胞癌中的表达及其与组织学分化的关系：免疫组织化学研究

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Introduction: Cyclin D1 oncogene is a key regulator of cell cycle progression associated with various human malignancies. Aim: To establish the prognostic significance of cyclin D1 in oral squamous cell carcinoma (OSCC) and to correlate its association with clinicopathological parameters. Materials and Methods: A retrospective study was carried out on 50 previously histopathologically diagnosed, formalin-fixed, paraffin embedded (FFPE) tissue samples of OSCC. Immunohistochemical analysis was performed in 50 cases of different grades of OSCC using a commercially available monoclonal anti-cyclin D1 antibody. Statistical Analysis Used: All the compiled data was statistically analyzed using Chi-square and Mann-Whitney test. P values of Results: Overexpression of cyclin D1 was seen in 68% cases of OSCC with a significant correlation with younger age group; no correlation was reported with respect to gender and site. The intergroup comparison of the cyclin D1 expression between well with poorly differentiated OSCC exhibited a significant correlation. Conclusions: The relative contribution of cyclin D1 expression in OSCC was significant according to the present study and further needs to be determined in large cohorts.
机译：简介：细胞周期蛋白D1癌基因是与各种人类恶性肿瘤相关的细胞周期进程的关键调节剂。目的：建立细胞周期蛋白D1在口腔鳞状细胞癌（OSCC）中的预后意义，并将其与临床病理参数相关联。材料和方法：回顾性研究对50例经组织病理学诊断，福尔马林固定，石蜡包埋（FFPE）的OSCC组织样本进行。使用市售的单克隆抗细胞周期蛋白D1抗体在50例不同等级的OSCC中进行了免疫组织化学分析。使用的统计分析：使用卡方检验和曼惠特尼检验对所有汇编数据进行统计分析。结果的P值：在68％的OSCC病例中发现细胞周期蛋白D1过表达，与年轻年龄组有显着相关性。没有关于性别和地点的相关报道。分化良好的OSCC与细胞周期蛋白D1表达的组间比较显示出显着的相关性。结论：根据本研究，cyclin D1表达在OSCC中的相对贡献是显着的，在大型人群中还需要确定。

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