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首页> 外文期刊>Journal of inflammation. >TNFRSF11B computational development network construction and analysis between frontal cortex of HIV encephalitis (HIVE) and HIVE-control patients
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TNFRSF11B computational development network construction and analysis between frontal cortex of HIV encephalitis (HIVE) and HIVE-control patients

机译：HIV脑炎（HIVE）与HIVE控制患者的额叶皮质之间TNFRSF11B计算开发网络的构建和分析

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Background TNFRSF11B computational development network construction and analysis of frontal cortex of HIV encephalitis (HIVE) is very useful to identify novel markers and potential targets for prognosis and therapy. Methods By integration of gene regulatory network infer (GRNInfer) and the database for annotation, visualization and integrated discovery (DAVID) we identified and constructed significant molecule TNFRSF11B development network from 12 frontal cortex of HIVE-control patients and 16 HIVE in the same GEO Dataset GDS1726. Results Our result verified TNFRSF11B developmental process only in the downstream of frontal cortex of HIVE-control patients (BST2, DGKG, GAS1, PDCD4, TGFBR3, VEZF1 inhibition), whereas in the upstream of frontal cortex of HIVE (DGKG, PDCD4 activation) and downstream (CFDP1, DGKG, GAS1, PAX6 activation; BST2, PDCD4, TGFBR3, VEZF1 inhibition). Importantly, we datamined that TNFRSF11B development cluster of HIVE is involved in T-cell mediated immunity, cell projection organization and cell motion (only in HIVE terms) without apoptosis, plasma membrane and kinase activity (only in HIVE-control patients terms), the condition is vital to inflammation, brain morphology and cognition impairment of HIVE. Our result demonstrated that common terms in both HIVE-control patients and HIVE include developmental process, signal transduction, negative regulation of cell proliferation, RNA-binding, zinc-finger, cell development, positive regulation of biological process and cell differentiation. Conclusions We deduced the stronger TNFRSF11B development network in HIVE consistent with our number computation. It would be necessary of the stronger TNFRSF11B development function to inflammation, brain morphology and cognition of HIVE.
机译：背景TNFRSF11B计算开发网络的构建和HIV脑炎（HIVE）额叶皮层的分析对于识别新型标志物和预后治疗的潜在靶点非常有用。方法通过整合基因调控网络推断（GRNInfer）和注释，可视化和整合发现数据库（DAVID），我们从12个HIVE控制患者的额叶皮层和16个HIVE在同一GEO数据集中识别并构建了重要的分子TNFRSF11B开发网络。 GDS1726。结果我们的结果证实了TNFRSF11B的发育过程仅在HIVE对照患者的额叶皮层的下游（BST2，DGKG，GAS1，PDCD4，TGFBR3，VEZF1抑制），而在HIVE额叶皮层的上游（DGKG，PDCD4激活）和下游（CFDP1，DGKG，GAS1，PAX6激活; BST2，PDCD4，TGFBR3，VEZF1抑制）。重要的是，我们通过数据挖掘发现，HIVE的TNFRSF11B发育簇与T细胞介导的免疫力，细胞投射组织和细胞运动（仅在HIVE方面）有关，而没有凋亡，质膜和激酶活性（仅对于HIVE对照患者而言），病情对于HIVE的炎症，脑形态和认知功能损害至关重要。我们的结果表明，在HIVE对照患者和HIVE中，常用术语包括发育过程，信号转导，细胞增殖的负调控，RNA结合，锌指，细胞发育，生物过程和细胞分化的正调控。结论我们推论出在HIVE中更强大的TNFRSF11B开发网络，这与我们的数量计算相符。 TNFRSF11B的更强发育功能对于炎症，脑形态和对HIVE的认知将是必要的。

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