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首页> 外文期刊>Journal of International Medical Research >Pharmacodynamic Characteristics of Low-Molecular-Weight Dermatan Sulphate after Subcutaneous Administration in Acute Myocardial Infarction
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Pharmacodynamic Characteristics of Low-Molecular-Weight Dermatan Sulphate after Subcutaneous Administration in Acute Myocardial Infarction

机译：皮下给药对急性心肌梗死后低分子量皮肤素硫酸盐的药效特性

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Sixteen patients (5 female and 11 male, mean age 59.1 years) who had had an acute myocardial infarction within the previous 7 days, were enrolled in an open pharmacodynamic study. Patients were randomly allocated to two treatment groups and given a single subcutaneous dose of 100 or 200 mg of a new low-molecular-weight dermatan sulphate. The drug pharmacodynamic profile was determined 1, 2, 4, 6, 8, 12 and 24 h after administration. The following coagulation and fibrinolysis tests were performed: activated partial thromboplastin time, thrombin time, activated factor X inhibition, Heptest (global clotting time), heparin cofactor II affinity, functional and antigenic plasminogen activator inhibitor and fibrin plate assay. Both Heptest and heparin cofactor II affinity were significantly increased (P < 0.001) in a dose-dependent manner. The Xal was enhanced, though to a lesser extent. None of the other coagulation or fibrinolysis tests showed significant changes at either dose. Systemic and local tolerance were always very good.
机译：在过去7天内患有急性心肌梗死的16例患者（5例女性和11例男性，平均年龄59.1岁）被纳入开放性药效学研究。将患者随机分配至两个治疗组，并单次皮下注射100或200 mg的新的低分子量硫酸皮肤素。在给药后1、2、4、6、8、12和24小时确定药物药效学特征。进行了以下凝血和纤溶测试：活化的部分凝血活酶时间，凝血酶时间，活化的X因子抑制作用，Heptest（整体凝血时间），肝素辅因子II亲和力，功能性和抗原性纤溶酶原激活剂抑制剂以及血纤蛋白板测定。 Heptest和肝素辅因子II亲和力均以剂量依赖性方式显着增加（P <0.001）。 Xal的增强程度有所降低。其他凝结或纤维蛋白溶解试验均未显示任何剂量都有明显变化。全身和局部耐受力始终很好。

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