Pharmacokinetics of the Bronchodilator Tulobuterol in Man after Repeated Oral Doses

L F Chasseaud; S G Wood

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Pharmacokinetics of the Bronchodilator Tulobuterol in Man after Repeated Oral Doses

机译：反复口服剂量的人中支气管扩张剂妥洛特罗的药代动力学

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Plasma levels and elimination half-life of tulobuterol, a new beta-adrenergic agonist, were determined in ten healthy male volunteers after repeated dosing with 2mg, twice daily, for seven days. Peak plasma levels attained (2.8 ±0.8 ng/ml), the time to peak plasma concentration (1.0 ±0.3 hr) and the elimination half-life (2.4 ±0.4 hr) were generally unchanged from the first to the final study dose. This suggests that tulobuterol does not accumulate in plasma after repeated administration of a dose regimen known to be clinically effective.

机译：在每天两次重复给药2mg，连续7天后，在十名健康的男性志愿者中确定了新的β-肾上腺素能激动剂妥洛特罗的血浆水平和消除半衰期。从首次研究剂量到最终研究剂量，达到的峰值血浆水平（2.8±0.8 ng / ml），达到峰值血浆浓度的时间（1.0±0.3 hr）和消除半衰期（2.4±0.4 hr）通常保持不变。这表明在重复施用已知临床有效的剂量方案后，妥洛特罗不会在血浆中蓄积。

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《Journal of International Medical Research》 |1986年第5期|共5页
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L F Chasseaud; S G Wood;
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中图分类药学;
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Pharmacokinetics of the Bronchodilator Tulobuterol in Man after Repeated Oral Doses

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